LINF_300037500

3-hydroxy-3-methylglutaryl-CoA reductase
Leishmania infantum JPCM5 OG6: OG6_101762 OG7: OG7_0005934 15 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 15 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LINF_180012200 ⚠
citrate synthase - putative
— Both
LINF_180012100 ⚠
citrate synthase - putative
— Both
LINF_080010700
eukaryotic translation initiation factor 2 be
— Both
LINF_250021900
mitochondrial RNA binding complex 1 subunit -
— Both
LINF_360055600
hypothetical protein - conserved
— Both
LINF_270024100
eRF1 domain 1/eRF1 domain 2/eRF1 domain 3 - p
— Both
LINF_160010500
aspartate carbamoyltransferase - putative
— Both
LINF_050008500
trypanothione reductase
— Both
LINF_350038800
6-phosphogluconate dehydrogenase - decarboxyl
— Both
LINF_260013400
hypothetical protein - conserved
— Both
LINF_160012200 ⚠
apurinic/apyrimidinic endonuclease-redox prot
— Both
LINF_200019400
hypothetical protein - conserved
— Both
LINF_290030800
enoyl-CoA hydratase/isomerase-like protein
— Both
LINF_290030700
ubiquitin hydrolase - putative
— Both
LINF_360062200 ⚠
endonuclease/exonuclease protein-like protein
— OG7
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.