LPAL13_060014300 – TrypsnetDB2

LPAL13_060014300

dihydrofolate reductase-thymidylate synthase

Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_101427 OG7: OG7_0003559 18 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 18 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LPAL13_140006600 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005562 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	Both
LPAL13_290024900 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001858 ↔ TCSYLVIO_003039	OG7
LPAL13_350042400 ⚠ Bromodomain, putative	—	OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005041	OG7
LPAL13_120014300 ⚠ puromycin-sensitive aminopeptidase-like prote	—	OG7 TCSYLVIO_001858 ↔ TCSYLVIO_003039	OG7
LPAL13_350080500 ⚠ DNA-binding protein, putative	—	OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005041	OG7
LPAL13_270019700 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	OG7
LPAL13_340005000 pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.7.5480 OG7 Tb927.10.14140 ↔ Tb927.7.5480	Both
LPAL13_290013000 guanine deaminase, putative	—	OG6 Tb927.5.4560 ↔ Tb927.7.5480 OG7 Tb927.5.4560 ↔ Tb927.7.5480	Both
LPAL13_320040900 glucosamine-6-phosphate isomerase, putative	—	OG6 Tb927.11.16770 ↔ Tb927.7.5480 OG7 Tb927.11.16770 ↔ Tb927.7.5480	Both
LPAL13_340005400 2-oxoisovalerate dehydrogenase beta subunit,	—	OG6 TCSYLVIO_000971 ↔ TCSYLVIO_001858 OG7 TCSYLVIO_000971 ↔ TCSYLVIO_001858	Both
LPAL13_350030700 tyrosine aminotransferase	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005122 OG6 TCSYLVIO_000769 ↔ TCSYLVIO_001858 OG7 TCSYLVIO_000769 ↔ TCSYLVIO_001858 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005122	Both
LPAL13_260007800 ⚠ aminopeptidase-like protein	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_003039 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_003039	Both
LPAL13_130006000 ⚠ carboxypeptidase, putative	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005562 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	Both
LPAL13_330034400 ⚠ carboxypeptidase, putative	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005562 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	Both
LPAL13_350038000 ⚠ bromodomain factor 2 protein, putative	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005041 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005041	Both
LPAL13_140006800 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005562 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	Both
LPAL13_140006700 ⚠ Carboxypeptidase Taq (M32) metallopeptidase,	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005562 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	Both
LPAL13_350072700 ⚠ Carboxypeptidase Taq (M32) metallopeptidase,	—	OG6 TCSYLVIO_001858 ↔ TCSYLVIO_005562 OG7 TCSYLVIO_001858 ↔ TCSYLVIO_005562	Both

Orthogroup expansion — connections between the query proteins

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