LPAL13_340005000

pyruvate kinase
Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_100258 OG7: OG7_0002165 185 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 185 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LPAL13_190005800 ⚠
acidocalcisomal pyrophosphatase
— Both
LPAL13_140017300
YjeF family N-terminal domain/YjeF family C-t
— Both
LPAL13_030013300 ⚠
inorganic pyrophosphatase, putative
— Both
LPAL13_130006500 ⚠
MCAK-like kinesin, putative
— OG7
LPAL13_340053900 ⚠
glyceraldehyde-3-phosphate dehydrogenase-like
— Both
LPAL13_150020000 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— Both
LPAL13_200036900
aldose 1-epimerase-like protein
— Both
LPAL13_200060400 ⚠
hypothetical protein, conserved
— OG6
LPAL13_130015300
adenylosuccinate synthetase, putative
— Both
LPAL13_110010200 ⚠
aminopeptidase, putative
— Both
LPAL13_340016000 ⚠
NADH-dependent fumarate reductase, putative
— Both
LPAL13_270016300
isovaleryl-coA dehydrogenase, putative
— Both
LPAL13_140006100 ⚠
inosine-guanine nucleoside hydrolase, putativ
— Both
LPAL13_010010000 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LPAL13_200060300 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LPAL13_290013000
guanine deaminase, putative
— Both
LPAL13_030007000 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LPAL13_300033900 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LPAL13_340016200 ⚠
NADH-dependent fumarate reductase, putative
— Both
LPAL13_060014300
dihydrofolate reductase-thymidylate synthase
— Both
LPAL13_320040900
glucosamine-6-phosphate isomerase, putative
— Both
LPAL13_000020300 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LPAL13_010010100 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LPAL13_200060500 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
LPAL13_000037600 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— Both
LPAL13_300009200
phosphatase 2C, putative
— OG6
LPAL13_280018000
electron-transfer-flavoprotein, alpha polypep
— Both
LPAL13_230025700
alanine racemase, putative
— Both
LPAL13_220008200
SEP domain containing protein, putative
— Both
LPAL13_200041400
phosphomannomutase-like protein
— Both
LPAL13_300019400 ⚠
Peptidase family M20/M25/M40, putative
— Both
LPAL13_300019500 ⚠
hypothetical protein
— Both
LPAL13_280028200
tRNA threonylcarbamoyl adenosine modification
— Both
LPAL13_300019600 ⚠
hypothetical protein
— Both
LPAL13_200065900 ⚠
N-acyl-L-amino acid amidohydrolase, putative
— Both
LPAL13_310017200 ⚠
N-acyl-L-amino acid amidohydrolase, putative
— Both
LPAL13_200065800 ⚠
hypothetical protein
— Both
LPAL13_320005800
N-myristoyl transferase, putative
— Both
LPAL13_310006400
ubiquitin hydrolase, putative
— Both
LPAL13_010006600
cyclophilin 12, putative
— OG6
LPAL13_330015000
nicotinate phosphoribosyltransferase, putativ
— Both
LPAL13_330037300 ⚠
transcription elongation factor-like protein
— Both
LPAL13_120010000
glucose-6-phosphate isomerase
— Both
LPAL13_270014000 ⚠
UBA/TS-N domain containing protein, putative
— Both
LPAL13_060016700
deoxyribose-phosphate aldolase, putative
— Both
LPAL13_130019500 ⚠
MCAK-like kinesin, putative
— OG7
LPAL13_000031000 ⚠
MCAK-like kinesin, putative
— OG7
LPAL13_280033000 ⚠
eukaryotic translation initiation factor 4e,
— OG7
LPAL13_350010700 ⚠
ubiquitin-like protein, putative
— OG7
LPAL13_300010000 ⚠
eukaryotic translation initiation factor 4e,
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.