LmxM.11.0630

metallo-peptidase, Clan MF, Family M17

Leishmania mexicana MHOM/GT/2001/U1103 OG6: OG6_142599 OG7: OG7_0003405 293 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 293 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LmxM.20.1550 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LmxM.20.1560 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LmxM.29.1380 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LmxM.30.1130 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LmxM.20.1570 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LmxM.20.1185 ⚠ calpain-like cysteine peptidase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
LmxM.01.0610 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG6 LdBPK_010630.1 ↔ LdBPK_110630.1 OG6 LdBPK_010630.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 +3 more	Both
LmxM.36.4040 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_110630.1 ↔ LdBPK_364240.1 OG6 LdBPK_110640.1 ↔ LdBPK_364240.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
LmxM.21.0895 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
LmxM.34.0830 ⚠ NADH-dependent fumarate reductase-like protei	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LmxM.33.2340 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG6 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 +1 more	Both
LmxM.20.1180 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
LmxM.29.0560 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
LmxM.34.1180 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LmxM.08.0410 ⚠ WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
LmxM.04.0450 ⚠ calpain-like cysteine peptidase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
LmxM.28.0330 ⚠ rrp44p homologue, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_280470.1 OG6 LdBPK_110640.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 +2 more	Both
LmxM.34.1190 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LmxM.07.0800 ⚠ flavoprotein subunit-like protein	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LmxM.28.0450 ⚠ DIS3-like exonuclease, putative	—	OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LmxM.29.0760 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG6 LdBPK_110630.1 ↔ LdBPK_300810.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	Both
LmxM.04.0330 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LmxM.36.5620 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LmxM.29.0460 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
LmxM.10.0160 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008446	OG7
LmxM.14.1320 ⚠ serine hydroxymethyltransferase, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010621	OG7
LmxM.24.0820 ⚠ inositol polyphosphate phosphatase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007569	OG7
LmxM.12.0190 ⚠ ubiquitin hydrolase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7
LmxM.11.0990 ⚠ adaptin-related protein-like protein	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_004597	OG7
LmxM.34.4230 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007569	OG7
LmxM.01.0710 ⚠ ubiquitin activating enzyme, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010542	OG7
LmxM.28.2370 ⚠ serine hydroxymethyltransferase	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010621	OG7
LmxM.14.0450 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010327	OG7
LmxM.17.0084 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.36.2600 ⚠ cyclin-e binding protein 1-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
LmxM.30.0310 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
LmxM.10.0195 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_291830.1	OG7
LmxM.34.3500 ⚠ zinc finger protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
LmxM.22.1430 ⚠ fk506-binding protein 1-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LmxM.23.0300 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_290060.1 OG7 LdBPK_110640.1 ↔ LdBPK_290060.1 OG7 LdBPK_290060.1 ↔ LdBPK_332700.1	OG7
LmxM.17.0086 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.34.4150 ⚠ hsp70 subfamily B suppressor 1, elongation fa	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.17.0085 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.17.0620 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
LmxM.17.0083 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.17.0082 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.33.2600 ⚠ acyl-CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
LmxM.17.0780 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
LmxM.17.0080 ⚠ elongation factor 1-alpha	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LmxM.21.0540 ⚠ Lupus La protein homolog, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_006827	OG7

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