TRSC58_00190

3-hydroxy-3-methylglutaryl-CoA reductase
Trypanosoma rangeli SC58 OG6: OG6_101762 OG7: OG7_0005934 15 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 15 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TRSC58_04944 ⚠
citrate synthase
— Both
TRSC58_02309 ⚠
citrate synthase
— Both
TRSC58_06387 ⚠
citrate synthase
— Both
TRSC58_01259
hypothetical protein
— Both
TRSC58_06213 ⚠
hypothetical protein
— Both
TRSC58_02162 ⚠
eukaryotic peptide chain release factor subun
— Both
TRSC58_00696
hypothetical protein
— Both
TRSC58_05217
translation initiation factor
— Both
TRSC58_02517
trypanothione reductase
— Both
TRSC58_07032
aspartate carbamoyltransferase
— Both
TRSC58_02154
6-phosphogluconate dehydrogenase, decarboxyla
— Both
TRSC58_05862 ⚠
apurinic/apyrimidinic endonuclease
— Both
TRSC58_05658
enoyl-CoA hydratase, mitochondrial precursor
— Both
TRSC58_06221
ubiquitin hydrolase
— Both
TRSC58_04128 ⚠
apurinic/apyrimidinic endonuclease
— OG7
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.