TRSC58_02989

pyroglutamyl-peptidase I (PGP)

Trypanosoma rangeli SC58 OG6: OG6_101530 OG7: OG7_0006024 135 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 135 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TRSC58_02286 ⚠ serine/threonine protein kinase	—	OG7 TCSYLVIO_009716 ↔ TCSYLVIO_010957	OG7
TRSC58_00039 hslvu complex proteolytic subunit	—	OG6 TCSYLVIO_008193 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_008193 ↔ TCSYLVIO_010957	Both
TRSC58_04836 hypothetical protein	—	OG6 TCSYLVIO_001163 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_001163 ↔ TCSYLVIO_010957	Both
TRSC58_03017 ⚠ phosphatase 2C	—	OG6 TCSYLVIO_003097 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	Both
TRSC58_00905 hypothetical protein	—	OG6 TCSYLVIO_000216 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_000216 ↔ TCSYLVIO_010957	Both
TRSC58_03408 ⚠ protein phosphatase 2C like protein 2/3	—	OG6 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	Both
TRSC58_03871 electron-transfer-flavoprotein, alpha polypep	—	OG6 TCSYLVIO_001784 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_001784 ↔ TCSYLVIO_010957	Both
TRSC58_03752 ⚠ hexokinase	—	OG6 TCSYLVIO_006856 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_006856 ↔ TCSYLVIO_010957	Both
TRSC58_06901 ⚠ hexokinase	—	OG6 TCSYLVIO_006856 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_006856 ↔ TCSYLVIO_010957	Both
TRSC58_03495 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	Both
TRSC58_05889 ⚠ protein phosphatase	—	OG6 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	Both
TRSC58_06174 isocitrate dehydrogenase	—	OG6 TCSYLVIO_010946 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_010946 ↔ TCSYLVIO_010957	Both
TRSC58_02970 ⚠ epsilon-adaptin	—	OG6 TCSYLVIO_003203 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003203 ↔ TCSYLVIO_010957	Both
TRSC58_06332 hypothetical protein	—	OG6 TCSYLVIO_004210 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_004210 ↔ TCSYLVIO_010957	Both
TRSC58_03666 phosphomannomutase-like protein	—	OG6 TCSYLVIO_003734 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003734 ↔ TCSYLVIO_010957	Both
TRSC58_01461 ⚠ hypothetical protein	—	OG6 TCSYLVIO_007293 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007293 ↔ TCSYLVIO_010957	Both
TRSC58_00045 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_009926 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_009926 ↔ TCSYLVIO_010957	Both
TRSC58_01208 N-myristoyl transferase	—	OG6 TCSYLVIO_006126 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_006126 ↔ TCSYLVIO_010957	Both
TRSC58_05983 ⚠ mitochondrial elongation factor G	—	OG6 TCSYLVIO_007487 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007487 ↔ TCSYLVIO_010957	Both
TRSC58_06291 ubiquitin hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_010957	Both
TRSC58_02525 hypothetical protein	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_010957	Both
TRSC58_02594 hypothetical protein	—	OG6 TCSYLVIO_004414 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_004414 ↔ TCSYLVIO_010957	Both
TRSC58_05656 nicotinate phosphoribosyltransferase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010957	Both
TRSC58_05901 35 kDa cyclophilin	—	OG6 TCSYLVIO_003462 ↔ TCSYLVIO_010957	OG6
TRSC58_03188 ⚠ transcription elongation factor-like protein	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_010957	Both
TRSC58_00152 deoxyribose-phosphate aldolase	—	OG6 TCSYLVIO_001881 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_001881 ↔ TCSYLVIO_010957	Both
TRSC58_03555 acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_010957	Both
TRSC58_04073 hypothetical protein	—	OG6 TCSYLVIO_010565 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_010565 ↔ TCSYLVIO_010957	Both
TRSC58_00238 UTP-glucose-1-phosphate uridylyltransferase 2	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010957	Both
TRSC58_01722 hypothetical protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010957	Both
TRSC58_06101 ⚠ MCAK-like kinesin	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_010957	OG7
TRSC58_03639 ⚠ protein kinase	—	OG7 TCSYLVIO_009716 ↔ TCSYLVIO_010957	OG7
TRSC58_05946 ⚠ protein kinase	—	OG7 TCSYLVIO_009716 ↔ TCSYLVIO_010957	OG7
TRSC58_06570 ⚠ kinesin family member 2/24	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_010957	OG7
TRSC58_03412 ⚠ hypothetical protein	—	OG7 TCSYLVIO_007293 ↔ TCSYLVIO_010957	OG7
TRSC58_01120 ⚠ hypothetical protein	—	OG7 TCSYLVIO_009926 ↔ TCSYLVIO_010957	OG7
TRSC58_06146 ⚠ hypothetical protein	—	OG7 TCSYLVIO_009926 ↔ TCSYLVIO_010957	OG7
TRSC58_00513 ⚠ glutaredoxin-like protein	—	OG7 Tb927.4.2670 ↔ Tb927.5.950	OG7
TRSC58_01601 ⚠ protein phosphatase 2C	—	OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	OG7
TRSC58_06237 ⚠ hypothetical protein	—	OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	OG7
TRSC58_04896 ⚠ protein phosphatase 2C	—	OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	OG7
TRSC58_00063 ⚠ protein phosphatase 2C	—	OG7 TCSYLVIO_007482 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_003097 ↔ TCSYLVIO_010957	OG7
TRSC58_01704 ubiquitin-like protein	—	OG7 TCSYLVIO_005459 ↔ TCSYLVIO_010957	OG7
TRSC58_05861 hypothetical protein	—	OG7 TCSYLVIO_006876 ↔ TCSYLVIO_010957	OG7
TRSC58_00005 ⚠ transcription elongation factor	—	OG7 TCSYLVIO_000382 ↔ TCSYLVIO_010957	OG7
TRSC58_02568 methylenetetrahydrofolate dehydrogenase-like	—	OG7 TCSYLVIO_002375 ↔ TCSYLVIO_010957	OG7
TRSC58_02248 ⚠ hypothetical protein	—	OG7 TCSYLVIO_002786 ↔ TCSYLVIO_010957	OG7
TRSC58_04142 ⚠ eukaryotic translation initiation factor	—	OG7 TCSYLVIO_005535 ↔ TCSYLVIO_010957	OG7
TRSC58_00501 ⚠ eukaryotic translation initiation factor 4E	—	OG7 TCSYLVIO_005535 ↔ TCSYLVIO_010957	OG7
TRSC58_02773 ⚠ hypothetical protein	—	OG7 TCSYLVIO_009926 ↔ TCSYLVIO_010957	OG7

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