TcCLB.508277.370

mitochondrial DNA topoisomerase II, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100284 OG7: OG7_0003182 25 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 25 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.507641.80 ⚠
5'-3' exoribonuclease D, putative
— Both
TcCLB.511305.10 ⚠
5'-3' exoribonuclease B, putative
— OG7
TcCLB.503955.20 ⚠
mitochondrial DNA polymerase beta, putative
— OG7
TcCLB.506847.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508723.70 ⚠
AAA domain containing protein, putative
— Both
TcCLB.508205.20 ⚠
nucleolar RNA helicase II, putative
— Both
TcCLB.507941.10 ⚠
Mitochondrial small ribosomal subunit uS10m,
— Both
TcCLB.508569.80 ⚠
phosphoacetylglucosamine mutase, putative
— Both
TcCLB.509099.80 ⚠
Mitochondrial small ribosomal subunit mS49, p
— Both
TcCLB.503953.59 ⚠
mitochondrial DNA polymerase beta-PAK, putati
— Both
TcCLB.503955.10 ⚠
mitochondrial DNA polymerase beta-PAK, putati
— Both
TcCLB.508127.5 ⚠
hypothetical protein, conserved
— Both
TcCLB.506735.50 ⚠
hypothetical protein, conserved
— Both
TcCLB.511691.20 ⚠
cystathionine beta-synthase, cysteine synthas
— Both
TcCLB.506351.9 ⚠
5'-3' exoribonuclease A, putative (fragment)
— Both
TcCLB.507817.80 ⚠
5'-3' exoribonuclease A, putative (fragment)
— Both
TcCLB.510025.170 ⚠
mucin TcMUCII, putative
— OG6
TcCLB.503967.10 ⚠
Mitochondrial large ribosomal subunit mL73, p
— Both
TcCLB.511691.10 ⚠
cysteine synthase, cystathionine beta-synthas
— Both
TcCLB.510381.10 ⚠
cystathionine beta-synthase, putative
— Both
TcCLB.507165.50 ⚠
cysteine synthase, putative
— OG6
TcCLB.508241.140 ⚠
serine sulfhydrylase, cysteine synthase, cyst
— Both
TcCLB.508241.149 ⚠
cystathionine beta-synthase, putative (fragme
— Both
TcCLB.509149.9 ⚠
cystathionine beta-synthase, serine sulfhydry
— Both
TcCLB.447925.10 ⚠
cystathionine beta-synthase, putative (fragme
— OG6
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.