TcCLB.447925.10

cystathionine beta-synthase, putative (fragment)
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100154 OG7: OGR7_0004156 66 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 66 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.508569.80 ⚠
phosphoacetylglucosamine mutase, putative
— OG6
TcCLB.503899.90 ⚠
asparagine synthetase a, putative
— OG6
TcCLB.504427.110 ⚠
acetyl-CoA synthetase, putative
— OG6
TcCLB.509099.50 ⚠
trypanothione synthetase
— OG6
TcCLB.506411.10 ⚠
metallo-peptidase, clan MA(E), family M3, put
— OG6
TcCLB.511211.170 ⚠
heat shock protein 70 (hsp70), putative
— OG6
TcCLB.511211.220 ⚠
heat shock protein 70, putative
— OG6
TcCLB.511211.160 ⚠
heat shock protein 70 (hsp70), putative
— OG6
TcCLB.506135.9 ⚠
heat shock 70 kDa protein, putative (fragment
— OG6
TcCLB.418069.10 ⚠
heat shock protein 70 (hsp70), putative (frag
— OG6
TcCLB.509137.30 ⚠
imidazolonepropionase, putative
— OG6
TcCLB.441401.10 ⚠
imidazolonepropienase, putative
— OG6
TcCLB.508813.15 ⚠
heat shock protein 70, putative (fragment)
— OG6
TcCLB.508127.5 ⚠
hypothetical protein, conserved
— OG6
TcCLB.506825.190 ⚠
hypothetical protein
— OG6
TcCLB.508647.280 ⚠
malic enzyme
— OG6
TcCLB.508647.270 ⚠
malic enzyme, putative
— OG6
TcCLB.509099.30 ⚠
paraflagellar rod protein 5, putative
— OG6
TcCLB.507807.20 ⚠
hypothetical protein, conserved
— OG6
TcCLB.509543.50 ⚠
DNAK protein, putative
— OG6
TcCLB.510751.4 ⚠
aminopeptidase P, putative
— OG6
TcCLB.507547.30 ⚠
Mitochondrial-processing peptidase subunit al
— OG6
TcCLB.503671.10 ⚠
Aminopeptidase M1, putative (fragment)
— OG6
TcCLB.507925.40 ⚠
pyridoxal kinase, putative
— OG6
TcCLB.510315.10 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— OG6
TcCLB.504033.130 ⚠
spermidine synthase, putative
— OG6
TcCLB.503855.20 ⚠
spermidine synthase, putative
— OG6
TcCLB.511071.140 ⚠
2-amino-3-ketobutyrate coenzyme A ligase, put
— OG6
TcCLB.506937.10 ⚠
cytosolic malate dehydrogenase, putative
— OG6
TcCLB.510507.20 ⚠
3-ketoacyl-CoA thiolase, putative
— OG6
TcCLB.511555.80 ⚠
ribonucleoside-diphosphate reductase small ch
— OG6
TcCLB.508993.10 ⚠
cytidine triphosphate synthase, putative
— OG6
TcCLB.504213.80 ⚠
threonine synthase, putative
— OG6
TcCLB.510325.69 ⚠
Aminopeptidase M1, putative (fragment)
— OG6
TcCLB.511559.20 ⚠
Uncharacterised protein family (UPF0160), put
— OG6
TcCLB.506811.190 ⚠
UDP-galactose 4-epimerase
— OG6
TcCLB.507611.340 ⚠
hypothetical protein, conserved
— OG6
TcCLB.509203.70 ⚠
DNA topoisomerase II, putative
— OG6
TcCLB.508277.370 ⚠
mitochondrial DNA topoisomerase II, putative
— OG6
TcCLB.509801.30 ⚠
citrate synthase, putative
— OG6
TcCLB.506945.330 ⚠
Protein of unknown function (DUF3808), putati
— OG6
TcCLB.504159.109 ⚠
NOL1/NOP2/sun family, putative
— OG6
TcCLB.507237.340 ⚠
Mucin-associated surface protein (MASP), subg
— OG6
TcCLB.504143.10 ⚠
hypothetical protein, conserved
— OG6
TcCLB.511691.20 ⚠
cystathionine beta-synthase, cysteine synthas
— OG6
TcCLB.510123.20 ⚠
mitogen-activated protein kinase 11, putative
— OG6
TcCLB.506925.150 ⚠
protein phosphatase 2C, putative
— OG6
TcCLB.506227.150 ⚠
protein kinase A regulatory subunit
— OG6
TcCLB.510565.11 ⚠
tyrosine aminotransferase, putative (fragment
— OG6
TcCLB.508537.5 ⚠
tyrosine aminotransferase, putative (fragment
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.