TcCLB.508647.270

malic enzyme, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100205 OG7: OG7_0002857 50 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 50 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506529.430 ⚠
alanine aminotransferase, putative, glutamic-
— Both
TcCLB.507165.50 ⚠
cysteine synthase, putative
— Both
TcCLB.504153.140 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
TcCLB.511211.220 ⚠
heat shock protein 70, putative
— OG6
TcCLB.510381.10 ⚠
cystathionine beta-synthase, putative
— OG6
TcCLB.511211.170 ⚠
heat shock protein 70 (hsp70), putative
— OG6
TcCLB.511691.10 ⚠
cysteine synthase, cystathionine beta-synthas
— OG6
TcCLB.509543.50 ⚠
DNAK protein, putative
— OG6
TcCLB.510737.100 ⚠
Peroxin 19
— Both
TcCLB.508813.15 ⚠
heat shock protein 70, putative (fragment)
— OG6
TcCLB.441401.10 ⚠
imidazolonepropienase, putative
— Both
TcCLB.509137.30 ⚠
imidazolonepropionase, putative
— Both
TcCLB.506529.420 ⚠
glutamic--pyruvic transaminase, putative, ala
— Both
TcCLB.508241.140 ⚠
serine sulfhydrylase, cysteine synthase, cyst
— OG6
TcCLB.504427.110 ⚠
acetyl-CoA synthetase, putative
— Both
TcCLB.509099.50 ⚠
trypanothione synthetase
— Both
TcCLB.507389.70 ⚠
peptidase, putative, metallo-peptidase, Clan
— Both
TcCLB.510243.80 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508771.20 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcCLB.508771.10 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcCLB.486465.9 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcCLB.504427.10 ⚠
trypanothione synthetase, putative
— OG7
TcCLB.504077.40 ⚠
translation elongation factor EF-2, putative
— OG7
TcCLB.509267.50 ⚠
U5 small nuclear ribonucleoprotein component,
— OG7
TcCLB.504867.20 ⚠
ABC transporter, putative
— OG7
TcCLB.509099.30 ⚠
paraflagellar rod protein 5, putative
— Both
TcCLB.507257.60 ⚠
Fumarate hydratase class I, cytosolic
— Both
TcCLB.506925.319 ⚠
isocitrate dehydrogenase, putative
— +2 more Both
TcCLB.507669.10 ⚠
fumarate hydratase, putative
— Both
TcCLB.507011.269 ⚠
6-phosphogluconate dehydrogenase, decarboxyla
— Both
TcCLB.511575.60 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— +2 more Both
TcCLB.509801.30 ⚠
citrate synthase, putative
— Both
TcCLB.508647.280 ⚠
malic enzyme
— Both
TcCLB.510751.4 ⚠
aminopeptidase P, putative
— Both
TcCLB.510749.99 ⚠
aminopeptidase P, putative
— Both
TcCLB.508169.20 ⚠
elongation factor 2, putative
— Both
TcCLB.510963.90 ⚠
elongation factor 2, putative
— Both
TcCLB.508169.9 ⚠
elongation factor 2, putative (fragment)
— Both
TcCLB.510737.10 ⚠
6-phosphogluconate dehydrogenase, decarboxyla
— Both
TcCLB.511691.20 ⚠
cystathionine beta-synthase, cysteine synthas
— OG6
TcCLB.503899.90 ⚠
asparagine synthetase a, putative
— Both
TcCLB.418069.10 ⚠
heat shock protein 70 (hsp70), putative (frag
— OG6
TcCLB.511559.20 ⚠
Uncharacterised protein family (UPF0160), put
— Both
TcCLB.506135.9 ⚠
heat shock 70 kDa protein, putative (fragment
— OG6
TcCLB.447925.10 ⚠
cystathionine beta-synthase, putative (fragme
— OG6
TcCLB.509149.9 ⚠
cystathionine beta-synthase, serine sulfhydry
— OG6
TcCLB.504431.100 ⚠
guanine deaminase, putative
— Both
TcCLB.511211.160 ⚠
heat shock protein 70 (hsp70), putative
— OG6
TcCLB.506825.190 ⚠
hypothetical protein
— Both
TcCLB.508241.149 ⚠
cystathionine beta-synthase, putative (fragme
— OG6
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.