TcCLB.504153.140

metallo-peptidase, Clan MF, Family M17

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_105603 OG7: OG7_0003405 237 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 237 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.506363.70 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
TcCLB.506363.90 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
TcCLB.506363.80 ⚠ N-acyl-L-amino acid amidohydrolase, putative,	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG7 LdBPK_110630.1 ↔ LdBPK_201720.1 OG7 LdBPK_110640.1 ↔ LdBPK_201720.1 OG7 LdBPK_110630.1 ↔ LdBPK_201740.1 +4 more	OG7
TcCLB.508535.10 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcCLB.509967.30 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcCLB.510777.20 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcCLB.510719.310 hypothetical protein, conserved	—	OG6 LdBPK_332700.1 ↔ LdBPK_364240.1 OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
TcCLB.511911.21 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcCLB.504137.10 isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcCLB.509595.50 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
TcCLB.508241.120 ⚠ rrp44p homologue, putative	—	OG6 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
TcCLB.507927.40 hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	OG7
TcCLB.510213.110 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcCLB.507809.110 WD domain, G-beta repeat, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	OG7
TcCLB.511585.40 DNA-damage inducible protein DDI1-like protei	—	OG6 LdBPK_010630.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG7 LdBPK_010630.1 ↔ LdBPK_110630.1 OG7 LdBPK_010630.1 ↔ LdBPK_332700.1 +1 more	Both
TcCLB.510215.10 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcCLB.503841.80 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcCLB.503467.9 ⚠ NADH-dependent fumarate reductase, putative (	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcCLB.506265.160 hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_341230.1 OG7 LdBPK_110640.1 ↔ LdBPK_341230.1 OG7 LdBPK_332700.1 ↔ LdBPK_341230.1	OG7
TcCLB.504867.110 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_160320.1 OG7 LdBPK_110640.1 ↔ LdBPK_160320.1 OG7 LdBPK_160320.1 ↔ LdBPK_332700.1	OG7
TcCLB.506457.130 Domain of unknown function (DUF4042), putativ	—	OG7 LdBPK_110640.1 ↔ LdBPK_211060.1	OG7
TcCLB.504153.10 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_271580.1 OG7 LdBPK_110640.1 ↔ LdBPK_271580.1 OG7 LdBPK_271580.1 ↔ LdBPK_332700.1	OG7
TcCLB.508183.4 aspartyl aminopeptidase, putative (fragment)	—	OG7 LdBPK_110640.1 ↔ LdBPK_292470.1	OG7
TcCLB.508213.9 ⚠ regulator of chromosome condensation, putativ	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcCLB.508239.30 ⚠ neurobeachin/beige-like protein, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_332920.1	OG7
TcCLB.506375.60 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_290060.1 OG7 LdBPK_110640.1 ↔ LdBPK_290060.1 OG7 LdBPK_290060.1 ↔ LdBPK_332700.1	OG7
TcCLB.464807.20 PA26 p53-induced protein (sestrin), putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_180660.1	OG7
TcCLB.510101.210 PUB domain containing protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_110920.1	OG7
TcCLB.508921.40 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
TcCLB.504427.50 5'-AMP-activated protein kinase subunit beta,	—	OG7 LdBPK_110640.1 ↔ LdBPK_230530.1	OG7
TcCLB.506945.270 ⚠ cyclin, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcCLB.506625.249 ⚠ RNA pseudouridylate synthase protein, putativ	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
TcCLB.509805.130 bifunctional aminoacyl-tRNA synthetase, putat	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
TcCLB.510525.30 hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_220710.1	OG7
TcCLB.511309.60 hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_171130.1	OG7
TcCLB.508465.60 hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_352820.1	OG7
TcCLB.510101.250 hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_110890.1	OG7
TcCLB.510105.70 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcCLB.511369.20 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcCLB.511751.70 microtubule associated protein xmap215	—	OG7 LdBPK_110640.1 ↔ LdBPK_301760.1	OG7
TcCLB.511911.71 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TcCLB.510249.14 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TcCLB.506517.149 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TcCLB.511369.10 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcCLB.506953.20 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TcCLB.508949.4 ⚠ elongation factor 1-alpha (ef-1-alpha), putat	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcCLB.508207.230 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_002376	OG7
TcCLB.506773.20 hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_001673	OG7
TcCLB.511369.5 ⚠ elongation factor 1-alpha, putative (fragment	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TcCLB.510749.40 ⚠ cysteine peptidase, Clan CA, family C19, puta	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7

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