TcCLB.508207.230

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_132778 OG7: OG7_0002306 146 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 146 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.508463.29 ⚠
Leucine carboxyl methyltransferase/Cupin-like
— OG7
TcCLB.507711.160 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509757.20 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcCLB.427247.10 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.510719.10 ⚠
vacuolar protein sorting-associated protein-l
— OG7
TcCLB.510853.50 ⚠
beta galactofuranosyl glycosyltransferase, pu
— OG7
TcCLB.503893.140 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.421959.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.507641.150 ⚠
Ribosomal protein S5, C-terminal domain conta
— OG7
TcCLB.480785.10 ⚠
serine/threonine kinase, putative, CMGC/DYRK
— OG7
TcCLB.408799.19 ⚠
isopentenyl-diphosphate delta-isomerase (frag
— OG7
TcCLB.506457.130 ⚠
Domain of unknown function (DUF4042), putativ
— OG7
TcCLB.508781.110 ⚠
2-oxoisovalerate dehydrogenase alpha subunit,
— OG7
TcCLB.504203.50 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.503811.10 ⚠
heat shock protein 90, putative
— OG7
TcCLB.506869.60 ⚠
protein kinase PK4, putative
— OG7
TcCLB.506739.190 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.507121.40 ⚠
beta galactofuranosyl glycosyltransferase, pu
— OG7
TcCLB.506591.4 ⚠
heat shock protein 90, putative
— OG7
TcCLB.504153.310 ⚠
heat shock protein, putative
— OG7
TcCLB.503447.60 ⚠
beta galactofuranosyl glycosyltransferase, pu
— OG7
TcCLB.510749.40 ⚠
cysteine peptidase, Clan CA, family C19, puta
— OG7
TcCLB.508781.20 ⚠
ATP synthase, putative
— OG7
TcCLB.508387.30 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.509967.30 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcCLB.506147.30 ⚠
synaptojanin (N-terminal domain), putative, i
— OG7
TcCLB.503479.70 ⚠
hook complex protein, conserved
— OG7
TcCLB.510101.150 ⚠
adaptin-related protein-like, putative
— OG7
TcCLB.510143.24 ⚠
Hsc70-interacting protein (Hip), putative
— OG7
TcCLB.508357.40 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
TcCLB.506673.60 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcCLB.509805.210 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506519.60 ⚠
CMGC/CLK family protein kinase, putative
— OG7
TcCLB.508717.40 ⚠
branch point binding protein, putative
— OG7
TcCLB.511353.40 ⚠
eukaryotic translation initiation factor 4E (
— OG7
TcCLB.511589.10 ⚠
ATP synthase, putative
— OG7
TcCLB.508675.9 ⚠
CMGC/DYRK protein kinase, putative (fragment)
— OG7
TcCLB.511801.10 ⚠
leucine rich repeat
— OG7
TcCLB.449247.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507521.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503975.50 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503975.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507511.40 ⚠
G5-interacting protein, putative
— OG7
TcCLB.507669.14 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511543.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511743.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510963.39 ⚠
PUB domain containing protein, putative
— OG7
TcCLB.509007.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506405.120 ⚠
V-type ATPase, A subunit, putative
— OG7
TcCLB.511731.80 ⚠
Mitochondrial small ribosomal subunit mS56, p
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.