TcCLB.506673.60

Adaptor protein complex AP-3 subunit beta-3
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_101595 OG7: OG7_0001921 203 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 203 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506221.30 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.410961.10 ⚠
phosphatidylinositol kinase related protein,
— OG7
TcCLB.506223.120 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
TcCLB.511435.49 ⚠
phosphatidylinositol 3-kinase, putative
— OG7
TcCLB.506533.34 ⚠
phosphatidylinositol kinase related protein,
— OG7
TcCLB.506773.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510515.100 ⚠
coronin, putative
— OG7
TcCLB.510243.50 ⚠
UMP/CMP kinase, putative
— OG7
TcCLB.509769.70 ⚠
DNA polymerase theta (helicase domain only),
— OG7
TcCLB.504051.20 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
TcCLB.504119.4 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
TcCLB.511115.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508181.140 ⚠
inorganic pyrophosphatase, putative
— OG7
TcCLB.507639.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508239.30 ⚠
neurobeachin/beige-like protein, putative
— OG7
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— OG7
TcCLB.511113.9 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcCLB.509011.20 ⚠
RNA polymerase IIA largest subunit, putative
— OG7
TcCLB.507641.14 ⚠
neurobeachin/beige protein, putative
— OG7
TcCLB.511625.40 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.510291.30 ⚠
protein phosphatase 2C-like, putative
— OG7
TcCLB.506739.200 ⚠
pyruvate dehydrogenase phosphatase
— OG7
TcCLB.503989.60 ⚠
protein phosphatase 2C, putative (fragment)
— OG7
TcCLB.506925.150 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506659.39 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.420989.10 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506885.270 ⚠
tubulin tyrosine ligase, putative
— OG7
TcCLB.509069.49 ⚠
DNA replication licensing factor MCM7, putati
— OG7
TcCLB.507527.30 ⚠
DNA replication licensing factor MCM6, putati
— OG7
TcCLB.508647.140 ⚠
DNA replication licensing factor MCM5, putati
— OG7
TcCLB.504427.200 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcCLB.506251.100 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcCLB.510751.10 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcCLB.509103.20 ⚠
tubulin-tyrosine ligase, putative
— OG7
TcCLB.506775.30 ⚠
tubulin-tyrosine ligase-like protein, putativ
— OG7
TcCLB.503897.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508995.30 ⚠
tubulin-tyrosine ligase, putative
— OG7
TcCLB.506941.80 ⚠
tubulin-tyrosine ligase-like protein, putativ
— OG7
TcCLB.510141.20 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
TcCLB.503637.20 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
TcCLB.509967.30 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcCLB.510777.20 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcCLB.511911.21 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503885.90 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— OG7
TcCLB.511075.40 ⚠
cullin, putative
— OG7
TcCLB.507395.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511867.170 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510105.40 ⚠
cullin-like protein, putative
— OG7
TcCLB.511585.40 ⚠
DNA-damage inducible protein DDI1-like protei
— OG7
TcCLB.511803.10 ⚠
cullin 2, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.