TcCLB.506223.120

phosphatidylinositol 3-related kinase, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_102609 OG7: OG7_0001934 315 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 315 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.509073.90 ⚠
CS domain/TPR repeat, putative
— OG7
TcCLB.508145.49 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509379.10 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
TcCLB.507757.60 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
TcCLB.507757.70 ⚠
dihydrolipoamide dehydrogenase, putative, ace
— OG7
TcCLB.508839.89 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
TcCLB.510879.120 ⚠
ribosomal protein L3, putative
— OG7
TcCLB.510879.110 ⚠
ribosomal protein L3, putative
— OG7
TcCLB.504427.140 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508647.210 ⚠
dynein arm light chain, putative
— OG7
TcCLB.509967.170 ⚠
dynein arm light chain, putative
— OG7
TcCLB.506211.200 ⚠
metallo-peptidase, Clan MG, Family M24
— OG7
TcCLB.504009.40 ⚠
Axonemal inner arm dynein light chain, putati
— OG7
TcCLB.506239.20 ⚠
Metallopeptidase family M24, putative
— OG7
TcCLB.414517.9 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcCLB.503529.10 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcCLB.506775.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503619.39 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506251.50 ⚠
Cell division control protein 48, putative
— OG7
TcCLB.506825.100 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510243.50 ⚠
UMP/CMP kinase, putative
— OG7
TcCLB.503479.30 ⚠
adenylate kinase 1
— OG7
TcCLB.506357.140 ⚠
Periodic tryptophan protein 2 homolog, putati
— OG7
TcCLB.506947.90 ⚠
adenylate kinase, putative
— OG7
TcCLB.504255.30 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509625.10 ⚠
ATP-dependent RNA helicase, putative (fragmen
— OG7
TcCLB.511315.9 ⚠
ATP-dependent RNA helicase, putative
— OG7
TcCLB.506179.59 ⚠
ATP-dependent RNA helicase, putative (fragmen
— OG7
TcCLB.509769.70 ⚠
DNA polymerase theta (helicase domain only),
— OG7
TcCLB.504051.20 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
TcCLB.511313.40 ⚠
ATP-dependent RNA helicase, putative
— OG7
TcCLB.511303.9 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506223.80 ⚠
Metalloprotease M41 FtsH, putative
— OG7
TcCLB.510105.210 ⚠
mitochondrial ATP-dependent zinc metallopepti
— OG7
TcCLB.506857.90 ⚠
proteasome regulatory ATPase subunit 1, putat
— OG7
TcCLB.511047.50 ⚠
proteasome regulatory ATPase subunit 2, putat
— OG7
TcCLB.511541.20 ⚠
hypothetical protein
— OG7
TcCLB.509893.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504147.200 ⚠
19S proteasome regulatory subunit, Regulatory
— OG7
TcCLB.506859.20 ⚠
proteasome regulatory ATPase subunit 5, putat
— OG7
TcCLB.510311.70 ⚠
26S protease regulatory subunit, putative, se
— OG7
TcCLB.506659.39 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506221.30 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.420989.10 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.503579.30 ⚠
DNA polymerase sigma-like protein, putative
— OG7
TcCLB.509007.70 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506925.150 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506739.200 ⚠
pyruvate dehydrogenase phosphatase
— OG7
TcCLB.503989.60 ⚠
protein phosphatase 2C, putative (fragment)
— OG7
TcCLB.509297.10 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.