TcCLB.509769.70

DNA polymerase theta (helicase domain only), putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_101025 OG7: OG7_0001850 134 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 134 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.503637.20 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
TcCLB.510599.14 ⚠
acetyl-CoA carboxylase (fragment)
— OG7
TcCLB.508369.50 ⚠
acetyl-CoA carboxylase (fragment)
— OG7
TcCLB.511217.100 ⚠
cullin 3, putative
— OG7
TcCLB.511803.10 ⚠
cullin 2, putative
— OG7
TcCLB.503813.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511075.40 ⚠
cullin, putative
— OG7
TcCLB.507395.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510105.40 ⚠
cullin-like protein, putative
— OG7
TcCLB.507875.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506357.130 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506739.200 ⚠
pyruvate dehydrogenase phosphatase
— OG7
TcCLB.443683.9 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
TcCLB.505945.80 ⚠
AKAP7 2'5' RNA ligase-like domain containing
— OG7
TcCLB.510291.30 ⚠
protein phosphatase 2C-like, putative
— OG7
TcCLB.507011.60 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
TcCLB.506925.40 ⚠
RNA polymerase I second largest subunit, puta
— OG7
TcCLB.426397.9 ⚠
kinesin, putative (fragment)
— OG7
TcCLB.510101.150 ⚠
adaptin-related protein-like, putative
— OG7
TcCLB.510771.9 ⚠
Thioredoxin-like/Protein of unknown function
— OG7
TcCLB.510753.30 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511217.160 ⚠
WW domain containing protein, putative
— OG7
TcCLB.507093.63 ⚠
RNA-binding protein, putative
— OG7
TcCLB.506673.60 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcCLB.504119.4 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
TcCLB.401473.9 ⚠
DNA-directed RNA polymerase I largest subunit
— OG7
TcCLB.507639.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511417.40 ⚠
DNA-directed RNA polymerase III, putative
— OG7
TcCLB.508387.70 ⚠
Mono-functional DNA-alkylating methyl methane
— OG7
TcCLB.506251.50 ⚠
Cell division control protein 48, putative
— OG7
TcCLB.511545.100 ⚠
RNA methyltransferase, putative
— OG7
TcCLB.508839.89 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
TcCLB.511115.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509967.189 ⚠
kinesin, putative (fragment)
— OG7
TcCLB.510773.9 ⚠
Thioredoxin-like/Protein of unknown function
— OG7
TcCLB.504643.49 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcCLB.504883.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.398751.10 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
TcCLB.509073.30 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
TcCLB.510749.40 ⚠
cysteine peptidase, Clan CA, family C19, puta
— OG7
TcCLB.508357.40 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
TcCLB.510311.50 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509489.29 ⚠
proteasome regulatory non-ATP-ase subunit, pu
— OG7
TcCLB.506625.200 ⚠
exosome complex exonuclease, putative, riboso
— OG7
TcCLB.509649.30 ⚠
19S proteasome non-atpase subunit 8
— OG7
TcCLB.511527.9 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
TcCLB.507809.80 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508169.9 ⚠
elongation factor 2, putative (fragment)
— OG7
TcCLB.510963.90 ⚠
elongation factor 2, putative
— OG7
TcCLB.504867.20 ⚠
ABC transporter, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.