TcCLB.504883.60

hypothetical protein, conserved
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_215239 OG7: OG7_0042808 99 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 99 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.507093.63
RNA-binding protein, putative
— OG7
TcCLB.511115.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508839.89 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
TcCLB.511075.40 ⚠
cullin, putative
— OG7
TcCLB.511545.100 ⚠
RNA methyltransferase, putative
— OG7
TcCLB.506251.50
Cell division control protein 48, putative
— OG7
TcCLB.508387.70 ⚠
Mono-functional DNA-alkylating methyl methane
— OG7
TcCLB.506943.160
eukaryotic translation initiation factor 3 su
— OG7
TcCLB.511417.40 ⚠
DNA-directed RNA polymerase III, putative
— OG7
TcCLB.507639.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.401473.9 ⚠
DNA-directed RNA polymerase I largest subunit
— OG7
TcCLB.504119.4 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
TcCLB.506673.60 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcCLB.510029.40 ⚠
DNA-directed RNA polymerase III subunit C11,
— OG7
TcCLB.509073.90
CS domain/TPR repeat, putative
— OG7
TcCLB.510771.9 ⚠
Thioredoxin-like/Protein of unknown function
— OG7
TcCLB.510101.150 ⚠
adaptin-related protein-like, putative
— OG7
TcCLB.503637.20 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
TcCLB.506925.40 ⚠
RNA polymerase I second largest subunit, puta
— OG7
TcCLB.510291.30 ⚠
protein phosphatase 2C-like, putative
— OG7
TcCLB.443683.9 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
TcCLB.506739.200 ⚠
pyruvate dehydrogenase phosphatase
— OG7
TcCLB.506357.130
hypothetical protein, conserved
— OG7
TcCLB.511001.130
hypothetical protein, conserved
— OG7
TcCLB.510089.200
Eukaryotic translation initiation factor 3 su
— OG7
TcCLB.511313.40 ⚠
ATP-dependent RNA helicase, putative
— OG7
TcCLB.506661.110
WD domain, G-beta repeat/Dip2/Utp12 Family, p
— OG7
TcCLB.506625.200
exosome complex exonuclease, putative, riboso
— OG7
TcCLB.510311.50
hypothetical protein, conserved
— OG7
TcCLB.503531.49 ⚠
structural maintenance of chromosome 3, putat
— OG7
TcCLB.507011.60 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
TcCLB.507813.10 ⚠
structural maintenance of chromosome 3 protei
— OG7
TcCLB.508779.90 ⚠
structural maintenance of chromosome protein
— OG7
TcCLB.509625.10 ⚠
ATP-dependent RNA helicase, putative (fragmen
— OG7
TcCLB.511315.9 ⚠
ATP-dependent RNA helicase, putative
— OG7
TcCLB.506179.59 ⚠
ATP-dependent RNA helicase, putative (fragmen
— OG7
TcCLB.509769.70 ⚠
DNA polymerase theta (helicase domain only),
— OG7
TcCLB.504051.20 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
TcCLB.509979.40
Zn-finger in Ran binding protein and others/S
— OG7
TcCLB.503897.20
hypothetical protein, conserved
— OG7
TcCLB.508717.30 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcCLB.510431.250 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcCLB.506607.19 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcCLB.503777.19 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcCLB.507809.30 ⚠
ribose-phosphate pyrophosphokinase, putative
— OG7
TcCLB.511625.40 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.507093.72
repressor activator protein 1
— OG7
TcCLB.509805.170 ⚠
pre-RNA processing PIH1/Nop17, putative
— OG7
TcCLB.504643.49
hypothetical protein, conserved (fragment)
— OG7
TcCLB.510773.9 ⚠
Thioredoxin-like/Protein of unknown function
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.