TcCLB.506925.40

RNA polymerase I second largest subunit, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_102249 OG7: OG7_0001821 187 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 187 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506625.200 ⚠
exosome complex exonuclease, putative, riboso
— Both
TcCLB.504119.4 ⚠
DNA-directed RNA polymerase III subunit C1, p
— +1 more OG7
TcCLB.507757.60 ⚠
dihydrolipoamide dehydrogenase, putative
— Both
TcCLB.509011.20 ⚠
RNA polymerase IIA largest subunit, putative
— +1 more OG7
TcCLB.506503.110 ⚠
DNA-directed RNA polymerases I and III subuni
— OG7
TcCLB.511801.44 ⚠
DNA-dependent RNA polymerases, putative
— OG7
TcCLB.507467.94 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509379.10 ⚠
dihydrolipoamide dehydrogenase, putative
— OG7
TcCLB.403789.9 ⚠
DNA-directed RNA polymerase I largest subunit
— +3 more Both
TcCLB.443683.9 ⚠
DNA-directed rna polymerase I largest subunit
— +3 more Both
TcCLB.506949.10 ⚠
DNA-directed rna polymerase I largest subunit
— +3 more Both
TcCLB.509767.180 ⚠
exosome component CSL4, putative
— Both
TcCLB.507757.70 ⚠
dihydrolipoamide dehydrogenase, putative, ace
— OG7
TcCLB.508839.89 ⚠
DNA-directed rna polymerase I largest subunit
— +3 more Both
TcCLB.401473.9 ⚠
DNA-directed RNA polymerase I largest subunit
— +3 more Both
TcCLB.511803.10 ⚠
cullin 2, putative
— OG7
TcCLB.511867.170 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511625.40 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.511075.40 ⚠
cullin, putative
— OG7
TcCLB.506885.290 ⚠
DNA replication licensing factor MCM9, putati
— OG7
TcCLB.510101.150 ⚠
adaptin-related protein-like, putative
— OG7
TcCLB.503637.20 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
TcCLB.510291.30 ⚠
protein phosphatase 2C-like, putative
— OG7
TcCLB.506739.200 ⚠
pyruvate dehydrogenase phosphatase
— OG7
TcCLB.508647.140 ⚠
DNA replication licensing factor MCM5, putati
— OG7
TcCLB.503989.60 ⚠
protein phosphatase 2C, putative (fragment)
— OG7
TcCLB.410961.10 ⚠
phosphatidylinositol kinase related protein,
— OG7
TcCLB.507527.30 ⚠
DNA replication licensing factor MCM6, putati
— OG7
TcCLB.506925.150 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506223.120 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
TcCLB.509069.49 ⚠
DNA replication licensing factor MCM7, putati
— OG7
TcCLB.504137.60 ⚠
beta adaptin, putative
— OG7
TcCLB.507813.10 ⚠
structural maintenance of chromosome 3 protei
— Both
TcCLB.503531.49 ⚠
structural maintenance of chromosome 3, putat
— Both
TcCLB.506357.130 ⚠
hypothetical protein, conserved
— Both
TcCLB.506743.210 ⚠
tubulin tyrosine ligase, putative
— Both
TcCLB.506933.80 ⚠
RNA polymerase B subunit RPB8, putative
— OG7
TcCLB.506221.30 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.420989.10 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506659.39 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.509151.80 ⚠
SpoU rRNA Methylase family, putative
— OG7
TcCLB.510105.40 ⚠
cullin-like protein, putative
— OG7
TcCLB.503425.29 ⚠
DNA replication licensing factor MCM8, putati
— OG7
TcCLB.511217.100 ⚠
cullin 3, putative
— OG7
TcCLB.504883.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511109.100 ⚠
DNA replication licensing factor MCM3, putati
— OG7
TcCLB.510293.40 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
TcCLB.506533.34 ⚠
phosphatidylinositol kinase related protein,
— OG7
TcCLB.511127.140 ⚠
DNA replication licensing factor MCM4, putati
— OG7
TcCLB.507395.20 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.