TcCLB.509011.20

RNA polymerase IIA largest subunit, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100210 OG7: OG7_0001854 179 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 179 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.508369.50 ⚠
acetyl-CoA carboxylase (fragment)
— Both
TcCLB.506503.110 ⚠
DNA-directed RNA polymerases I and III subuni
— +2 more Both
TcCLB.506607.19 ⚠
phosphoribosylpyrophosphate synthetase, putat
— Both
TcCLB.507809.30 ⚠
ribose-phosphate pyrophosphokinase, putative
— Both
TcCLB.510599.14 ⚠
acetyl-CoA carboxylase (fragment)
— Both
TcCLB.503777.19 ⚠
phosphoribosylpyrophosphate synthetase, putat
— Both
TcCLB.509951.49 ⚠
DNA-directed RNA polymerase II subunit 2, put
— +4 more Both
TcCLB.511417.40 ⚠
DNA-directed RNA polymerase III, putative
— +4 more Both
TcCLB.508717.30 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcCLB.510431.250 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcCLB.506925.40 ⚠
RNA polymerase I second largest subunit, puta
— +1 more OG7
TcCLB.506525.162 ⚠
Flagellum attachment zone protein 9 (fragment
— OG7
TcCLB.511075.40 ⚠
cullin, putative
— OG7
TcCLB.511545.100 ⚠
RNA methyltransferase, putative
— OG7
TcCLB.511393.30 ⚠
formin homology 2 (FH2) domain protein, putat
— OG7
TcCLB.506251.50 ⚠
Cell division control protein 48, putative
— OG7
TcCLB.506863.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508387.70 ⚠
Mono-functional DNA-alkylating methyl methane
— OG7
TcCLB.506885.290 ⚠
DNA replication licensing factor MCM9, putati
— OG7
TcCLB.509067.40 ⚠
NADH dehydrogenase subunit NI8M, putative
— OG7
TcCLB.507639.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.401473.9 ⚠
DNA-directed RNA polymerase I largest subunit
— OG7
TcCLB.506673.60 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcCLB.507093.63 ⚠
RNA-binding protein, putative
— OG7
TcCLB.510771.9 ⚠
Thioredoxin-like/Protein of unknown function
— OG7
TcCLB.510101.150 ⚠
adaptin-related protein-like, putative
— OG7
TcCLB.503637.20 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
TcCLB.506527.4 ⚠
Flagellum attachment zone protein 9 (fragment
— OG7
TcCLB.506633.100 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510291.30 ⚠
protein phosphatase 2C-like, putative
— OG7
TcCLB.443683.9 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
TcCLB.506925.150 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.510243.50 ⚠
UMP/CMP kinase, putative
— OG7
TcCLB.509199.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508921.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510879.30 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506945.359 ⚠
damage-specific DNA binding protein, putative
— OG7
TcCLB.506941.260 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507757.70 ⚠
dihydrolipoamide dehydrogenase, putative, ace
— OG7
TcCLB.508239.30 ⚠
neurobeachin/beige-like protein, putative
— OG7
TcCLB.506203.80 ⚠
formin-like protein
— OG7
TcCLB.506223.120 ⚠
phosphatidylinositol 3-related kinase, putati
— OG7
TcCLB.503989.60 ⚠
protein phosphatase 2C, putative (fragment)
— OG7
TcCLB.506357.130 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508647.140 ⚠
DNA replication licensing factor MCM5, putati
— OG7
TcCLB.447255.4 ⚠
ubiquitin, putative
— OG7
TcCLB.511625.40 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.510285.20 ⚠
PQQ-like domain/WD domain, G-beta repeat/Utp2
— OG7
TcCLB.504427.140 ⚠
hypothetical protein, conserved
— OG7
TcCLB.403789.9 ⚠
DNA-directed RNA polymerase I largest subunit
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.