TcCLB.509595.50

DIS3-like exonuclease, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_102526 OG7: OG7_0002439 206 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 206 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506925.260 ⚠
Atypical serine/threonine protein kinase BUD3
— +1 more Both
TcCLB.506363.70 ⚠
amidohydrolase, putative
— Both
TcCLB.506363.90 ⚠
amidohydrolase, putative
— Both
TcCLB.506363.80 ⚠
N-acyl-L-amino acid amidohydrolase, putative,
— OG7
TcCLB.503639.10 ⚠
inositol-3-phosphate synthase, putative
— +1 more Both
TcCLB.504153.140 ⚠
metallo-peptidase, Clan MF, Family M17
— +1 more Both
TcCLB.510181.9 ⚠
inositol-3-phosphate synthase, putative (frag
— +1 more Both
TcCLB.509551.140 ⚠
hypothetical protein, conserved
— +1 more Both
TcCLB.504883.50 ⚠
tRNA synthetases class II (A)/Threonyl and Al
— Both
TcCLB.511733.110 ⚠
GTPase activating protein of Rab-like GTPase,
— OG7
TcCLB.511041.50 ⚠
flagellum transition zone component, putative
— OG7
TcCLB.511353.10 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
TcCLB.506493.50 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
TcCLB.510751.10 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcCLB.503653.60 ⚠
cytochrome b-domain protein, putative
— OG7
TcCLB.508723.100 ⚠
rab-like GTPase activating protein, putative
— OG7
TcCLB.506375.10 ⚠
tryptophanyl-tRNA synthetase, putative
— OG7
TcCLB.507875.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510611.40 ⚠
Ankyrin repeats (3 copies), putative
— OG7
TcCLB.511001.60 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcCLB.509803.40 ⚠
5-oxoprolinase, putative
— OG7
TcCLB.508955.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508927.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510741.220 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511737.10 ⚠
small glutamine-rich tetratricopeptide repeat
— OG7
TcCLB.511307.6 ⚠
NOL1/NOP2/sun family, putative
— OG7
TcCLB.511801.14 ⚠
protein lipid droplet kinase (LDK)
— OG7
TcCLB.509805.220 ⚠
cholinephosphate cytidylyltransferase A, puta
— OG7
TcCLB.509103.4 ⚠
protein kinase, putative
— OG7
TcCLB.503865.40 ⚠
Programmed cell death protein 2, C-terminal p
— OG7
TcCLB.507993.140 ⚠
RNA-binding protein 29, putative
— OG7
TcCLB.504203.29 ⚠
tRNA-dihydrouridine synthase 2, putative
— OG7
TcCLB.506773.44 ⚠
cytochrome b5, putative
— OG7
TcCLB.506375.60 ⚠
tryptophanyl-tRNA synthetase, putative
— OG7
TcCLB.506265.180 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509805.30 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506467.50 ⚠
serine/threonine protein kinase, putative
— OG7
TcCLB.507047.160 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510257.130 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcCLB.509381.10 ⚠
mitochondrial import receptor subunit, putati
— OG7
TcCLB.510091.100 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506513.50 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcCLB.504427.200 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcCLB.503811.10 ⚠
heat shock protein 90, putative
— OG7
TcCLB.511217.160 ⚠
WW domain containing protein, putative
— OG7
TcCLB.509127.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507713.30 ⚠
heat shock protein 85, putative
— OG7
TcCLB.504431.109 ⚠
cytochrome b5, putative
— OG7
TcCLB.506591.4 ⚠
heat shock protein 90, putative
— OG7
TcCLB.506251.100 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.