TcCLB.506363.90

amidohydrolase, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_101553 OG7: OG7_0005942 145 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 145 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.504153.140 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
TcCLB.508241.120 ⚠ rrp44p homologue, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_280470.1 OG6 LdBPK_201740.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 +1 more	Both
TcCLB.509595.50 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
TcCLB.504137.10 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
TcCLB.511041.50 ⚠ flagellum transition zone component, putative	—	OG7 LdBPK_201720.1 ↔ LdBPK_366480.1 OG7 LdBPK_201740.1 ↔ LdBPK_366480.1	OG7
TcCLB.509537.10 ⚠ pre-mRNA splicing factor ATP-dependent RNA he	—	OG6 LdBPK_201720.1 ↔ LdBPK_241120.1 OG6 LdBPK_201740.1 ↔ LdBPK_241120.1	OG6
TcCLB.511801.60 ⚠ DEAD-box ATP-dependent RNA helicase, mitochon	—	OG6 LdBPK_201720.1 ↔ LdBPK_282220.1 OG6 LdBPK_201740.1 ↔ LdBPK_282220.1 OG7 LdBPK_201720.1 ↔ LdBPK_282220.1 OG7 LdBPK_201740.1 ↔ LdBPK_282220.1	Both
TcCLB.510431.220 ⚠ ribosome assembly protein RRB1, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_332020.1 OG6 LdBPK_201740.1 ↔ LdBPK_332020.1 OG7 LdBPK_201720.1 ↔ LdBPK_332020.1 OG7 LdBPK_201740.1 ↔ LdBPK_332020.1	Both
TcCLB.506127.50 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_271580.1 OG6 LdBPK_201740.1 ↔ LdBPK_271580.1 OG7 LdBPK_201720.1 ↔ LdBPK_271580.1 OG7 LdBPK_201740.1 ↔ LdBPK_271580.1	Both
TcCLB.506363.70 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_201740.1 OG7 LdBPK_201720.1 ↔ LdBPK_201740.1	Both
TcCLB.506289.60 ⚠ Cupin-like domain containing protein, putativ	—	OG6 LdBPK_201720.1 ↔ LdBPK_261270.1 OG6 LdBPK_201740.1 ↔ LdBPK_261270.1 OG7 LdBPK_201720.1 ↔ LdBPK_261270.1 OG7 LdBPK_201740.1 ↔ LdBPK_261270.1	Both
TcCLB.503885.100 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_241960.1 OG6 LdBPK_201740.1 ↔ LdBPK_241960.1 OG7 LdBPK_201720.1 ↔ LdBPK_241960.1 OG7 LdBPK_201740.1 ↔ LdBPK_241960.1	Both
TcCLB.503909.84 ⚠ calpain-like cysteine peptidase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_302040.1 OG6 LdBPK_201740.1 ↔ LdBPK_302040.1	OG6
TcCLB.511577.50 ⚠ endo-beta-N-acetylglucosaminidase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_332390.1 OG6 LdBPK_201740.1 ↔ LdBPK_332390.1 OG7 LdBPK_201720.1 ↔ LdBPK_332390.1 OG7 LdBPK_201740.1 ↔ LdBPK_332390.1	Both
TcCLB.511555.80 ⚠ ribonucleoside-diphosphate reductase small ch	—	OG6 LdBPK_201720.1 ↔ LdBPK_221110.1 OG6 LdBPK_201740.1 ↔ LdBPK_221110.1 OG7 LdBPK_201720.1 ↔ LdBPK_221110.1 OG7 LdBPK_201740.1 ↔ LdBPK_221110.1	Both
TcCLB.509167.170 ⚠ tRNA (Guanine-1)-methyltransferase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_303110.1 OG6 LdBPK_201740.1 ↔ LdBPK_303110.1 OG7 LdBPK_201720.1 ↔ LdBPK_303110.1 OG7 LdBPK_201740.1 ↔ LdBPK_303110.1	Both
TcCLB.508469.59 ⚠ helicase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_352320.1 OG6 LdBPK_201740.1 ↔ LdBPK_352320.1	OG6
TcCLB.507735.10 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_341570.1 OG6 LdBPK_201740.1 ↔ LdBPK_341570.1 OG7 LdBPK_201720.1 ↔ LdBPK_341570.1 OG7 LdBPK_201740.1 ↔ LdBPK_341570.1	Both
TcCLB.508271.30 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_271580.1 OG6 LdBPK_201740.1 ↔ LdBPK_271580.1 OG7 LdBPK_201720.1 ↔ LdBPK_271580.1 OG7 LdBPK_201740.1 ↔ LdBPK_271580.1	Both
TcCLB.510769.30 ⚠ U3 small nucleolar RNA-associated protein 6,	—	OG6 LdBPK_201720.1 ↔ LdBPK_351980.1 OG6 LdBPK_201740.1 ↔ LdBPK_351980.1 OG7 LdBPK_201720.1 ↔ LdBPK_351980.1 OG7 LdBPK_201740.1 ↔ LdBPK_351980.1	Both
TcCLB.507883.109 ⚠ mitochondrial malate dehydrogenase, putative	—	OG6 TCSYLVIO_004390 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004390 ↔ TCSYLVIO_008414	Both
TcCLB.510877.55 ⚠ acyl-CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
TcCLB.506953.20 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
TcCLB.506517.149 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
TcCLB.510249.14 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
TcCLB.511911.71 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
TcCLB.505989.82 ⚠ ruvB-like DNA helicase, putative	—	OG7 TCSYLVIO_003846 ↔ TCSYLVIO_008414	OG7
TcCLB.504153.300 ⚠ GTPase protein, putative	—	OG7 LdBPK_050200.1 ↔ LdBPK_201720.1 OG7 LdBPK_050200.1 ↔ LdBPK_201740.1	OG7
TcCLB.506287.150 ⚠ GTP-binding protein, putative	—	OG7 LdBPK_050200.1 ↔ LdBPK_201720.1 OG7 LdBPK_050200.1 ↔ LdBPK_201740.1	OG7
TcCLB.510609.30 ⚠ GTPase, putative	—	OG7 LdBPK_050200.1 ↔ LdBPK_201720.1 OG7 LdBPK_050200.1 ↔ LdBPK_201740.1	OG7
TcCLB.504867.110 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_160320.1 ↔ LdBPK_201720.1 OG7 LdBPK_160320.1 ↔ LdBPK_201740.1	OG7
TcCLB.506503.69 ⚠ glycosomal malate dehydrogenase, putative	—	OG7 TCSYLVIO_004390 ↔ TCSYLVIO_008414	OG7
TcCLB.507883.100 ⚠ malate dehydrogenase, putative	—	OG7 TCSYLVIO_004390 ↔ TCSYLVIO_008414	OG7
TcCLB.503805.9 ⚠ Quinonprotein alcohol dehydrogenase-like prot	—	OG7 LdBPK_200680.1 ↔ LdBPK_301440.1	OG7
TcCLB.511369.5 ⚠ elongation factor 1-alpha, putative (fragment	—	OG7 LdBPK_201720.1 ↔ LdBPK_354220.1 OG7 LdBPK_201740.1 ↔ LdBPK_354220.1	OG7
TcCLB.506925.10 ⚠ hypothetical protein	—	OG7 LdBPK_201720.1 ↔ LdBPK_241960.1 OG7 LdBPK_201740.1 ↔ LdBPK_241960.1	OG7
TcCLB.511353.10 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 LdBPK_201720.1 ↔ LdBPK_291330.1 OG7 LdBPK_201740.1 ↔ LdBPK_291330.1	OG7
TcCLB.506925.260 ⚠ Atypical serine/threonine protein kinase BUD3	—	OG7 LdBPK_201720.1 ↔ LdBPK_331490.1 OG7 LdBPK_201740.1 ↔ LdBPK_331490.1	OG7
TcCLB.509805.40 ⚠ Multisite-specific tRNA:(cytosine-C(5))-methy	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_008414	OG7
TcCLB.506213.120 ⚠ ATP-dependent RNA helicase HEL67	—	OG7 LdBPK_201720.1 ↔ LdBPK_282220.1 OG7 LdBPK_201740.1 ↔ LdBPK_282220.1	OG7
TcCLB.507841.30 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_201720.1 ↔ LdBPK_261200.1 OG7 LdBPK_201740.1 ↔ LdBPK_261200.1	OG7
TcCLB.503551.20 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_201720.1 ↔ LdBPK_241960.1 OG7 LdBPK_201740.1 ↔ LdBPK_241960.1	OG7
TcCLB.511369.10 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_201720.1 ↔ LdBPK_354220.1 OG7 LdBPK_201740.1 ↔ LdBPK_354220.1	OG7
TcCLB.417091.10 ⚠ RNA pseudouridylate synthase, putative	—	OG7 LdBPK_201720.1 ↔ LdBPK_261140.1 OG7 LdBPK_201740.1 ↔ LdBPK_261140.1	OG7
TcCLB.511571.10 ⚠ ATP-dependent DEAD/H RNA helicase, putative	—	OG7 LdBPK_201720.1 ↔ LdBPK_282220.1 OG7 LdBPK_201740.1 ↔ LdBPK_282220.1	OG7
TcCLB.507811.30 ⚠ ATP-dependent DEAD/H RNA helicase, putative	—	OG7 LdBPK_201720.1 ↔ LdBPK_282220.1 OG7 LdBPK_201740.1 ↔ LdBPK_282220.1	OG7
TcCLB.506249.20 ⚠ protein transport protein Sec23A, putative	—	OG7 LdBPK_100330.1 ↔ LdBPK_201720.1 OG7 LdBPK_100330.1 ↔ LdBPK_201740.1	OG7
TcCLB.503959.50 ⚠ hypothetical protein, conserved	—	OG7 Tb927.1.3000 ↔ Tb927.6.2970	OG7
TcCLB.507713.30 ⚠ heat shock protein 85, putative	—	OG7 TCSYLVIO_005578 ↔ TCSYLVIO_008414	OG7
TcCLB.506211.150 ⚠ polyprenyl synthase, putative	—	OG7 LdBPK_190210.1 ↔ LdBPK_201720.1 OG7 LdBPK_190210.1 ↔ LdBPK_201740.1	OG7

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