TcCLB.509805.40

Multisite-specific tRNA:(cytosine-C(5))-methyltransferase, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_139680 OG7: OG7_0004943 132 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 132 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506363.130 ⚠
tRNA (Uracil-5-)-methyltransferase, putative
— OG7
TcCLB.503811.10 ⚠
heat shock protein 90, putative
— OG7
TcCLB.506505.40 ⚠
Calcium/calmodulin-dependent protein kinase k
— OG7
TcCLB.504867.20 ⚠
ABC transporter, putative
— OG7
TcCLB.511421.60 ⚠
deoxyhypusine synthase, putative
— OG7
TcCLB.503639.10 ⚠
inositol-3-phosphate synthase, putative
— OG7
TcCLB.506467.40 ⚠
serine/threonine protein kinase, putative
— OG7
TcCLB.504421.10 ⚠
serine/threonine protein kinase, putative
— OG7
TcCLB.507713.40 ⚠
heat shock protein 85, putative (fragment)
— OG7
TcCLB.506363.90 ⚠
amidohydrolase, putative
— OG7
TcCLB.506363.70 ⚠
amidohydrolase, putative
— OG7
TcCLB.507993.260 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506925.260 ⚠
Atypical serine/threonine protein kinase BUD3
— OG7
TcCLB.506363.80 ⚠
N-acyl-L-amino acid amidohydrolase, putative,
— OG7
TcCLB.506107.20 ⚠
dihydrouridine synthase (Dus), putative
— OG7
TcCLB.504203.29 ⚠
tRNA-dihydrouridine synthase 2, putative
— OG7
TcCLB.503599.10 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcCLB.504073.30 ⚠
ribonucleoside-diphosphate reductase large ch
— OG7
TcCLB.504153.140 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
TcCLB.510283.70 ⚠
glycosyl hydrolase-like protein, putative
— OG7
TcCLB.510053.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508089.30 ⚠
N-terminal conserved domain of Nudc./CS domai
— OG7
TcCLB.510181.9 ⚠
inositol-3-phosphate synthase, putative (frag
— OG7
TcCLB.503589.10 ⚠
GDP-mannose pyrophosphorylase
— OG7
TcCLB.510999.30 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509551.140 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510407.90 ⚠
serine hydroxymethyltransferase, putative
— OG7
TcCLB.503637.30 ⚠
serine peptidase, Clan SC, Family S9B
— OG7
TcCLB.504119.29 ⚠
deoxyhypusine synthase, putative
— OG7
TcCLB.506265.180 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506375.60 ⚠
tryptophanyl-tRNA synthetase, putative
— OG7
TcCLB.506467.50 ⚠
serine/threonine protein kinase, putative
— OG7
TcCLB.507907.50 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506513.50 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcCLB.510089.110 ⚠
mitochondrial RNA binding complex 1 subunit,
— OG7
TcCLB.506375.10 ⚠
tryptophanyl-tRNA synthetase, putative
— OG7
TcCLB.458015.10 ⚠
VHS domain containing protein, putative
— OG7
TcCLB.510999.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503959.50 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511751.180 ⚠
pseudouridine synthase A-like protein, putati
— OG7
TcCLB.503579.110 ⚠
pseudouridylate synthase I, putative
— OG7
TcCLB.510617.19 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508387.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504035.90 ⚠
translation initiation factor IF-2, putative
— OG7
TcCLB.506405.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511049.40 ⚠
leucyl-tRNA synthetase, putative
— OG7
TcCLB.510533.120 ⚠
translation initiation factor IF-2, putative
— OG7
TcCLB.507929.20 ⚠
co-chaperone GrpE, putative
— OG7
TcCLB.509167.100 ⚠
valyl-tRNA synthetase, putative
— OG7
TcCLB.509247.50 ⚠
methionyl-tRNA synthetase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.