TcCLB.503579.110

pseudouridylate synthase I, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_133986 OG7: OG7_0002342 141 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 141 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.503479.70 ⚠
hook complex protein, conserved
— OG7
TcCLB.510431.220 ⚠
ribosome assembly protein RRB1, putative
— OG7
TcCLB.504153.140 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
TcCLB.509805.210 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506519.60 ⚠
CMGC/CLK family protein kinase, putative
— OG7
TcCLB.508717.40 ⚠
branch point binding protein, putative
— OG7
TcCLB.508675.9 ⚠
CMGC/DYRK protein kinase, putative (fragment)
— OG7
TcCLB.511589.10 ⚠
ATP synthase, putative
— OG7
TcCLB.427247.10 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.511571.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.508535.10 ⚠
NADH-dependent fumarate reductase, putative
— OG7
TcCLB.508207.230 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
TcCLB.511427.19 ⚠
conserved protein, unknown function (fragment
— OG7
TcCLB.511911.21 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510777.20 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcCLB.509967.30 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcCLB.510609.130 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506859.70 ⚠
guide RNA associated protein, GAP2, putative
— OG7
TcCLB.508569.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506773.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507669.160 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509537.80 ⚠
TPR repeat, putative
— OG7
TcCLB.464807.20 ⚠
PA26 p53-induced protein (sestrin), putative
— OG7
TcCLB.503487.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.509757.30 ⚠
stress-inducible protein STI1-like, putative
— OG7
TcCLB.509381.10 ⚠
mitochondrial import receptor subunit, putati
— OG7
TcCLB.506885.320 ⚠
TPR repeat/Tetratricopeptide repeat, putative
— OG7
TcCLB.509127.110 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511627.100 ⚠
TPR-repeat protein, putative
— OG7
TcCLB.511737.10 ⚠
small glutamine-rich tetratricopeptide repeat
— OG7
TcCLB.511585.40 ⚠
DNA-damage inducible protein DDI1-like protei
— OG7
TcCLB.506249.20 ⚠
protein transport protein Sec23A, putative
— OG7
TcCLB.511575.100 ⚠
protein transport protein SEC23, putative
— OG7
TcCLB.506625.249 ⚠
RNA pseudouridylate synthase protein, putativ
— OG7
TcCLB.506135.90 ⚠
RNA pseudouridylate synthase, putative
— OG7
TcCLB.417091.10 ⚠
RNA pseudouridylate synthase, putative
— OG7
TcCLB.511211.220 ⚠
heat shock protein 70, putative
— OG7
TcCLB.506363.80 ⚠
N-acyl-L-amino acid amidohydrolase, putative,
— OG7
TcCLB.506945.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504159.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510747.170 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511729.9 ⚠
calmodulin, putative (fragment)
— OG7
TcCLB.511709.19 ⚠
phosphatidylinositol 3-kinase catalytic subun
— OG7
TcCLB.510749.4 ⚠
ubiquitin-protein ligase, putative
— OG7
TcCLB.506363.90 ⚠
amidohydrolase, putative
— OG7
TcCLB.506363.70 ⚠
amidohydrolase, putative
— OG7
TcCLB.509007.20 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506289.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511429.20 ⚠
cyclophilin 15, putative
— OG7
TcCLB.511067.10 ⚠
tubulin folding cofactor D, putative
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.