TcCLB.511067.10

tubulin folding cofactor D, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_102599 OG7: OG7_0006853 181 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 181 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.509967.30 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
TcCLB.511421.110 ⚠ developmentally regulated phosphoprotein, put	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	Both
TcCLB.510751.10 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	OG7
TcCLB.507809.110 WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_010560	Both
TcCLB.511911.21 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
TcCLB.510777.20 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
TcCLB.509805.130 bifunctional aminoacyl-tRNA synthetase, putat	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
TcCLB.506127.30 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 LdBPK_191010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005548	Both
TcCLB.508271.10 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 LdBPK_191010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005548	Both
TcCLB.506183.9 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG6 LdBPK_240010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 +1 more	Both
TcCLB.506251.100 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
TcCLB.504427.200 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
TcCLB.507537.30 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	Both
TcCLB.506531.60 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_120255.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	Both
TcCLB.506529.590 ⚠ Centrosomal protein of 164 kDa, putative	—	OG6 LdBPK_120470.1 ↔ LdBPK_242100.1 OG7 LdBPK_120470.1 ↔ LdBPK_242100.1	Both
TcCLB.427247.10 ⚠ CMGC/DYRK protein kinase, putative	—	OG7 TCSYLVIO_001302 ↔ TCSYLVIO_009362	OG7
TcCLB.508539.30 hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005125	Both
TcCLB.507993.280 ⚠ zinc-finger of a C2HC-type/Double zinc ribbon	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006138 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006138	Both
TcCLB.507841.30 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_242100.1 ↔ LdBPK_261200.1	OG7
TcCLB.510349.30 phosphatidylinositol-4-phosphate 5-kinase, pu	—	OG7 LdBPK_242100.1 ↔ LdBPK_291830.1	OG7
TcCLB.506127.170 ⚠ Eukaryotic translation initiation factor 4E-1	—	OG7 LdBPK_242100.1 ↔ LdBPK_300460.1	OG7
TcCLB.511435.20 ⚠ Replication Factor C Subunit 1-related protei	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcCLB.510737.110 ⚠ replication factor C, subunit 3, putative	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcCLB.511589.160 ⚠ replication factor C, subunit 4, putative	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcCLB.511741.30 ⚠ replication factor C, subunit 2, putative	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcCLB.506517.100 ⚠ ATPase family associated with various cellula	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcCLB.507875.10 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcCLB.509965.350 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcCLB.509007.20 hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002919 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_002919	Both
TcCLB.503841.80 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both
TcCLB.506859.70 guide RNA associated protein, GAP2, putative	—	OG6 TCSYLVIO_001262 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_001302	Both
TcCLB.509803.40 5-oxoprolinase, putative	—	OG6 LdBPK_181050.1 ↔ LdBPK_242100.1 OG7 LdBPK_181050.1 ↔ LdBPK_242100.1	Both
TcCLB.511001.190 vacuolar ATP synthase subunit d, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005104 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005104	Both
TcCLB.503589.10 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007603	Both
TcCLB.503613.60 ⚠ acidocalcisomal pyrophosphatase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001709 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001709	Both
TcCLB.503855.40 ⚠ calpain-like cysteine peptidase, putative, cy	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007342	OG6
TcCLB.506625.60 ⚠ inositol 5-phosphatase 1, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007569	Both
TcCLB.509805.210 hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006238 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006238	Both
TcCLB.508569.130 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_004468 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_004468 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_002376	Both
TcCLB.508717.40 branch point binding protein, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_004728 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_004728	Both
TcCLB.511545.140 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006138	OG6
TcCLB.511585.40 DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003428 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003428	Both
TcCLB.509543.50 ⚠ DNAK protein, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002696	OG6
TcCLB.511731.80 Mitochondrial small ribosomal subunit mS56, p	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003353 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003353	Both
TcCLB.506773.20 hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001673 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001673	Both
TcCLB.508207.230 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002376 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_004468 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_002376	Both
TcCLB.508813.15 ⚠ heat shock protein 70, putative (fragment)	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002696	OG6
TcCLB.508535.10 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both
TcCLB.511211.170 ⚠ heat shock protein 70 (hsp70), putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002696	OG6
TcCLB.511571.40 hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008446 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_008446	Both

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