TcCLB.508569.130

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100250 OG7: OG7_0002306 158 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 158 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.507711.160 ⚠
hypothetical protein, conserved
— Both
TcCLB.508463.29 ⚠
Leucine carboxyl methyltransferase/Cupin-like
— Both
TcCLB.509757.20 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcCLB.507537.30 ⚠
cysteinyl-tRNA synthetase, putative
— OG7
TcCLB.504153.140 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
TcCLB.503449.30 ⚠
clathrin coat assembly protein, putative
— OG7
TcCLB.510777.29 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.509777.100 ⚠
ubiquitin-activating enzyme, putative
— OG7
TcCLB.506265.70 ⚠
hypothetical protein, conserved
— OG7
TcCLB.486901.10 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
TcCLB.508347.120 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507713.40 ⚠
heat shock protein 85, putative (fragment)
— OG7
TcCLB.506531.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503689.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510431.140 ⚠
dual specificity tyrosine-phosphorylation-reg
— OG7
TcCLB.503697.120 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504137.60 ⚠
beta adaptin, putative
— OG7
TcCLB.506635.70 ⚠
Zeta toxin, putative
— OG7
TcCLB.509073.30 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
TcCLB.506183.9 ⚠
pyruvate dehydrogenase (lipoamide) kinase, pu
— OG7
TcCLB.511575.40 ⚠
exonuclease, putative
— OG7
TcCLB.511585.130 ⚠
ubiquitin activating enzyme, putative
— OG7
TcCLB.503589.10 ⚠
GDP-mannose pyrophosphorylase
— OG7
TcCLB.504935.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.506127.30 ⚠
phenylalanyl-tRNA synthetase, putative
— OG7
TcCLB.503637.30 ⚠
serine peptidase, Clan SC, Family S9B
— OG7
TcCLB.506127.170 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
TcCLB.507809.110 ⚠
WD domain, G-beta repeat, putative
— OG7
TcCLB.511421.110 ⚠
developmentally regulated phosphoprotein, put
— OG7
TcCLB.511145.60 ⚠
ATP synthase F1 subunit gamma protein, putati
— OG7
TcCLB.503893.140 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.421959.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.508271.10 ⚠
phenylalanyl-tRNA synthetase, putative
— OG7
TcCLB.510351.90 ⚠
dihydrolipoamide branched chain transacylase,
— OG7
TcCLB.480785.10 ⚠
serine/threonine kinase, putative, CMGC/DYRK
— OG7
TcCLB.507927.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504203.50 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.503811.10 ⚠
heat shock protein 90, putative
— OG7
TcCLB.511181.80 ⚠
threonyl-tRNA synthetase, putative
— OG7
TcCLB.506739.190 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.506591.4 ⚠
heat shock protein 90, putative
— OG7
TcCLB.504153.310 ⚠
heat shock protein, putative
— OG7
TcCLB.510515.100 ⚠
coronin, putative
— OG7
TcCLB.506885.320 ⚠
TPR repeat/Tetratricopeptide repeat, putative
— OG7
TcCLB.509381.10 ⚠
mitochondrial import receptor subunit, putati
— OG7
TcCLB.509757.30 ⚠
stress-inducible protein STI1-like, putative
— OG7
TcCLB.509537.80 ⚠
TPR repeat, putative
— OG7
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— OG7
TcCLB.503579.110 ⚠
pseudouridylate synthase I, putative
— OG7
TcCLB.503885.90 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.