TcCLB.506183.9

pyruvate dehydrogenase (lipoamide) kinase, putative (fragment)

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_146742 OG7: OG7_0002830 123 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 123 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.506251.100 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 LdBPK_230660.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 +1 more	Both
TcCLB.504427.200 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 LdBPK_230660.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 +1 more	Both
TcCLB.507537.30 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 +1 more	Both
TcCLB.506531.60 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_120255.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 +1 more	Both
TcCLB.511067.10 ⚠ tubulin folding cofactor D, putative	—	OG6 LdBPK_240010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 +1 more	Both
TcCLB.511421.110 ⚠ developmentally regulated phosphoprotein, put	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_007262 OG6 Tb927.1.1000 ↔ Tb927.11.4780 OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	Both
TcCLB.508271.10 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG6 LdBPK_191010.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 +1 more	Both
TcCLB.508183.4 ⚠ aspartyl aminopeptidase, putative (fragment)	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_004406 OG6 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	Both
TcCLB.506127.30 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG6 LdBPK_191010.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 +1 more	Both
TcCLB.510751.10 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcCLB.511911.21 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcCLB.510777.20 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcCLB.509967.30 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcCLB.507011.80 zinc finger protein, putative	—	OG6 LdBPK_240010.1 ↔ LdBPK_353550.1	OG6
TcCLB.506753.210 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_091450.1 ↔ LdBPK_200310.1	OG7
TcCLB.506755.50 ⚠ PPPDE putative peptidase domain containing pr	—	OG6 LdBPK_240010.1 ↔ LdBPK_240660.1 OG7 LdBPK_240010.1 ↔ LdBPK_240660.1	Both
TcCLB.511421.200 ARM-like helical domain-containing protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_312230.1	OG6
TcCLB.506237.19 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_240010.1 ↔ LdBPK_291830.1	OG6
TcCLB.506755.90 ⚠ PPPDE putative peptidase domain containing pr	—	OG6 LdBPK_240010.1 ↔ LdBPK_240660.1 OG7 LdBPK_240010.1 ↔ LdBPK_240660.1	Both
TcCLB.510181.90 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_240010.1 ↔ LdBPK_362610.1 OG7 LdBPK_240010.1 ↔ LdBPK_362610.1	Both
TcCLB.480997.10 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_240010.1 ↔ LdBPK_291830.1	OG6
TcCLB.510741.10 ⚠ cystathione gamma lyase, putative	—	OG6 LdBPK_140470.1 ↔ LdBPK_240010.1 OG7 LdBPK_140470.1 ↔ LdBPK_240010.1	Both
TcCLB.510739.19 ⚠ cystathione gamma lyase, putative (fragment)	—	OG6 LdBPK_140470.1 ↔ LdBPK_240010.1 OG7 LdBPK_140470.1 ↔ LdBPK_240010.1	Both
TcCLB.506525.50 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_161200.1 ↔ LdBPK_240010.1 OG7 LdBPK_161200.1 ↔ LdBPK_240010.1	Both
TcCLB.503885.90 ⚠ WD domain, G-beta repeat/PFU (PLAA family ubi	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_007262	Both
TcCLB.509803.40 ⚠ 5-oxoprolinase, putative	—	OG6 LdBPK_181050.1 ↔ LdBPK_240010.1 OG7 LdBPK_181050.1 ↔ LdBPK_240010.1	Both
TcCLB.504153.140 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001670	OG7
TcCLB.503903.70 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_030950.1 ↔ LdBPK_200310.1	OG7
TcCLB.508387.160 ⚠ Phosphatidylinositol 4-phosphate 5-kinase, pu	—	OG7 LdBPK_030950.1 ↔ LdBPK_200310.1	OG7
TcCLB.509965.350 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_240010.1	OG7
TcCLB.507875.10 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_161180.1 ↔ LdBPK_240010.1	OG7
TcCLB.510963.50 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002376	OG7
TcCLB.508181.20 ⚠ 6-phosphofructo-2-kinase 1	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002376	OG7
TcCLB.508569.130 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002376	OG7
TcCLB.503479.70 ⚠ hook complex protein, conserved	—	OG7 TCSYLVIO_005619 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005619	OG7
TcCLB.510749.40 ⚠ cysteine peptidase, Clan CA, family C19, puta	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005373 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005374	OG7
TcCLB.508357.40 ⚠ ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005373 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005374	OG7
TcCLB.510101.150 ⚠ adaptin-related protein-like, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
TcCLB.506947.80 ⚠ arginine N-methyltransferase, type I	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
TcCLB.503811.10 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcCLB.508169.69 ⚠ peptidyl-prolyl cis-trans isomerase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
TcCLB.506591.4 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcCLB.504153.310 ⚠ heat shock protein, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcCLB.506147.30 ⚠ synaptojanin (N-terminal domain), putative, i	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcCLB.510737.60 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
TcCLB.509145.19 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000902 ↔ TCSYLVIO_007262	OG7
TcCLB.450061.10 ⚠ Glycerophosphoryl diester phosphodiesterase f	—	OG7 TCSYLVIO_000902 ↔ TCSYLVIO_007262	OG7
TcCLB.509153.60 ⚠ lipin, putative	—	OG7 TCSYLVIO_001856 ↔ TCSYLVIO_007262	OG7
TcCLB.510311.140 ⚠ arginine N-methyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
TcCLB.506673.60 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7

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