TcCLB.509805.130

bifunctional aminoacyl-tRNA synthetase, putative, prolyl-tRNA synthetase, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100749 OG7: OG7_0002333 175 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 175 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.511067.10 tubulin folding cofactor D, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
TcCLB.506859.70 guide RNA associated protein, GAP2, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_220520.1 OG6 TCSYLVIO_001262 ↔ TCSYLVIO_006246 OG7 LdBPK_181230.1 ↔ LdBPK_220520.1 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_006246	Both
TcCLB.507537.30 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcCLB.506531.60 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcCLB.511911.21 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcCLB.510777.20 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcCLB.509967.30 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcCLB.503479.70 ⚠ hook complex protein, conserved	—	OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	OG7
TcCLB.509805.210 hypothetical protein, conserved	—	OG6 TCSYLVIO_006238 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 TCSYLVIO_006238 ↔ TCSYLVIO_006246	Both
TcCLB.510431.220 ⚠ ribosome assembly protein RRB1, putative	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	Both
TcCLB.510737.110 ⚠ replication factor C, subunit 3, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcCLB.508647.40 ⚠ replication factor C, subunit 1, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_241010.1 OG6 LdBPK_181230.1 ↔ LdBPK_241010.1 OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	Both
TcCLB.509965.350 ⚠ ubiquitin-protein ligase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_300970.1 OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	Both
TcCLB.507711.320 DNA mismatch repair protein MSH2, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_330420.1 OG7 LdBPK_181230.1 ↔ LdBPK_330420.1	Both
TcCLB.503479.49 ⚠ U6 snRNA-associated Sm-like protein LSm7p	—	OG6 LdBPK_181230.1 ↔ LdBPK_260010.1 OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	Both
TcCLB.504935.10 ⚠ Eukaryotic translation initiation factor 4E-4	—	OG6 LdBPK_181220.1 ↔ LdBPK_300460.1 OG6 LdBPK_181230.1 ↔ LdBPK_300460.1 OG7 LdBPK_181220.1 ↔ LdBPK_300460.1 OG7 LdBPK_181230.1 ↔ LdBPK_300460.1	Both
TcCLB.506375.80 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_230360.1 OG6 LdBPK_181230.1 ↔ LdBPK_230360.1 OG7 LdBPK_181220.1 ↔ LdBPK_230360.1 OG7 LdBPK_181230.1 ↔ LdBPK_230360.1	Both
TcCLB.506127.30 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_191010.1 OG6 LdBPK_181230.1 ↔ LdBPK_191010.1 OG7 LdBPK_181220.1 ↔ LdBPK_191010.1 OG7 LdBPK_181230.1 ↔ LdBPK_191010.1	Both
TcCLB.506135.70 hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_261160.1 OG7 LdBPK_181230.1 ↔ LdBPK_261160.1	Both
TcCLB.480997.10 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_291830.1 OG6 LdBPK_181230.1 ↔ LdBPK_291830.1	OG6
TcCLB.511577.50 endo-beta-N-acetylglucosaminidase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_332390.1 OG7 LdBPK_181230.1 ↔ LdBPK_332390.1	Both
TcCLB.511111.10 translation initiation factor IF-2, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_332880.1 OG6 LdBPK_181230.1 ↔ LdBPK_332880.1 OG7 LdBPK_181220.1 ↔ LdBPK_332880.1 OG7 LdBPK_181230.1 ↔ LdBPK_332880.1	Both
TcCLB.511351.9 ⚠ inosine-5'-monophosphate dehydrogenase, putat	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1 OG7 LdBPK_181220.1 ↔ LdBPK_191590.1 OG7 LdBPK_181230.1 ↔ LdBPK_191590.1	Both
TcCLB.506885.380 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_354870.1 OG6 LdBPK_181230.1 ↔ LdBPK_354870.1 OG7 LdBPK_181220.1 ↔ LdBPK_354870.1 OG7 LdBPK_181230.1 ↔ LdBPK_354870.1	Both
TcCLB.511585.40 DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_003428 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_006246	Both
TcCLB.510101.250 hypothetical protein, conserved	—	OG6 LdBPK_110890.1 ↔ LdBPK_181220.1 OG6 LdBPK_110890.1 ↔ LdBPK_181230.1 OG7 LdBPK_110890.1 ↔ LdBPK_181220.1 OG7 LdBPK_110890.1 ↔ LdBPK_181230.1	Both
TcCLB.503653.20 hypothetical protein, conserved	—	OG6 LdBPK_020280.1 ↔ LdBPK_181220.1 OG6 LdBPK_020280.1 ↔ LdBPK_181230.1 OG7 LdBPK_020280.1 ↔ LdBPK_181220.1 OG7 LdBPK_020280.1 ↔ LdBPK_181230.1	Both
TcCLB.506857.110 Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_006246	Both
TcCLB.509007.20 hypothetical protein, conserved	—	OG6 TCSYLVIO_002919 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002919 ↔ TCSYLVIO_006246	Both
TcCLB.506733.60 N(2), N(2)-dimethylguanosine tRNA methyltrans	—	OG6 TCSYLVIO_002844 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_006246	Both
TcCLB.507809.110 WD domain, G-beta repeat, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_181220.1 OG6 LdBPK_080420.1 ↔ LdBPK_181230.1 OG7 LdBPK_080420.1 ↔ LdBPK_181220.1 OG7 LdBPK_080420.1 ↔ LdBPK_181230.1	Both
TcCLB.506529.590 ⚠ Centrosomal protein of 164 kDa, putative	—	OG6 LdBPK_120470.1 ↔ LdBPK_181220.1 OG6 LdBPK_120470.1 ↔ LdBPK_181230.1 OG7 LdBPK_120470.1 ↔ LdBPK_181220.1 OG7 LdBPK_120470.1 ↔ LdBPK_181230.1	Both
TcCLB.507925.69 hypothetical protein, conserved	—	OG6 TCSYLVIO_003179 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_006246	Both
TcCLB.509803.40 5-oxoprolinase, putative	—	OG6 LdBPK_181050.1 ↔ LdBPK_181220.1 OG6 LdBPK_181050.1 ↔ LdBPK_181230.1 OG7 LdBPK_181050.1 ↔ LdBPK_181220.1 OG7 LdBPK_181050.1 ↔ LdBPK_181230.1	Both
TcCLB.507993.280 ⚠ zinc-finger of a C2HC-type/Double zinc ribbon	—	OG6 TCSYLVIO_006138 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	Both
TcCLB.511545.140 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG6
TcCLB.503893.140 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcCLB.504203.50 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcCLB.508387.30 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcCLB.504153.140 metallo-peptidase, Clan MF, Family M17	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
TcCLB.507875.10 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
TcCLB.510963.50 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
TcCLB.508207.230 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
TcCLB.507797.9 ⚠ nuclear transcription factor, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_220007.1 OG7 LdBPK_181230.1 ↔ LdBPK_220007.1	OG7
TcCLB.506517.100 ⚠ ATPase family associated with various cellula	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcCLB.511741.30 ⚠ replication factor C, subunit 2, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcCLB.504147.190 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_181230.1 ↔ LdBPK_321150.1	OG7
TcCLB.509127.110 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001559 ↔ TCSYLVIO_006246	OG7
TcCLB.509381.10 ⚠ mitochondrial import receptor subunit, putati	—	OG7 TCSYLVIO_001559 ↔ TCSYLVIO_006246	OG7
TcCLB.506885.320 ⚠ TPR repeat/Tetratricopeptide repeat, putative	—	OG7 TCSYLVIO_001559 ↔ TCSYLVIO_006246	OG7

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