TcCLB.511421.60

deoxyhypusine synthase, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_101093 OG7: OG7_0005231 125 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 125 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.504119.29 ⚠ deoxyhypusine synthase, putative	—	OG6 TCSYLVIO_004558 ↔ TCSYLVIO_007258 OG6 Tb927.1.870 ↔ Tb927.10.2750 OG7 Tb927.1.870 ↔ Tb927.10.2750 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_007258	Both
TcCLB.504421.10 ⚠ serine/threonine protein kinase, putative	—	OG7 TCSYLVIO_005149 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_005149	OG7
TcCLB.506351.80 ⚠ serine peptidase, clan SC, family S9A-like pr	—	OG6 TCSYLVIO_006546 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_006546 ↔ TCSYLVIO_007258	Both
TcCLB.511557.10 ⚠ oligopeptidase b	—	OG6 TCSYLVIO_006546 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_006546 ↔ TCSYLVIO_007258	Both
TcCLB.506857.110 ⚠ Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_007258	Both
TcCLB.510533.120 ⚠ translation initiation factor IF-2, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007258	Both
TcCLB.510617.19 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007258	Both
TcCLB.508387.10 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007258	Both
TcCLB.506289.60 ⚠ Cupin-like domain containing protein, putativ	—	OG6 TCSYLVIO_002279 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002279 ↔ TCSYLVIO_004558	Both
TcCLB.509757.30 ⚠ stress-inducible protein STI1-like, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_007258	Both
TcCLB.511627.100 ⚠ TPR-repeat protein, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_007258	Both
TcCLB.506863.10 ⚠ alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007258	Both
TcCLB.509595.50 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007258 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007258 +4 more	Both
TcCLB.429257.10 ⚠ Gar1/Naf1 RNA binding region, putative	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007258	Both
TcCLB.508181.140 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007258	Both
TcCLB.503613.60 ⚠ acidocalcisomal pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007258	Both
TcCLB.510525.10 ⚠ calcium/calmodulin-dependent protein kinase,	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.508241.120 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007258	OG7
TcCLB.510257.130 ⚠ CAMK/CAMKL family protein kinase, putative	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.510861.140 ⚠ CAMK/CAMKL family protein kinase, putative	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.464807.10 ⚠ serine/threonine protein kinase, putative, CA	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.511801.14 ⚠ protein lipid droplet kinase (LDK)	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.511001.60 ⚠ CAMK/CAMKL family protein kinase, putative	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.506493.50 ⚠ CAMK/CAMKL pseudokinase, putative	—	OG7 TCSYLVIO_004355 ↔ TCSYLVIO_004558	OG7
TcCLB.506287.30 ⚠ cytochrome b5-like Heme/Steroid binding domai	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007258	OG7
TcCLB.506773.44 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007258	OG7
TcCLB.507047.160 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007258	OG7
TcCLB.506753.110 ⚠ cytochrome b5-like protein, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007258	OG7
TcCLB.504431.109 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007258	OG7
TcCLB.503653.60 ⚠ cytochrome b-domain protein, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007258	OG7
TcCLB.504867.20 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006012	OG7
TcCLB.506505.40 ⚠ Calcium/calmodulin-dependent protein kinase k	—	OG7 TCSYLVIO_005149 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_005149	OG7
TcCLB.506885.320 ⚠ TPR repeat/Tetratricopeptide repeat, putative	—	OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_007258	OG7
TcCLB.506375.10 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010724	OG7
TcCLB.511733.110 ⚠ GTPase activating protein of Rab-like GTPase,	—	OG7 TCSYLVIO_004558 ↔ TCSYLVIO_008881	OG7
TcCLB.506265.180 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_009102	OG7
TcCLB.506375.60 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010724	OG7
TcCLB.508321.50 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010624	OG7
TcCLB.511217.200 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_010624	OG7
TcCLB.504203.29 ⚠ tRNA-dihydrouridine synthase 2, putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_009102	OG7
TcCLB.506107.20 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007258 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_009102	OG7
TcCLB.504035.90 ⚠ translation initiation factor IF-2, putative	—	OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007258	OG7
TcCLB.508955.20 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_006877 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_006877	OG7
TcCLB.511307.6 ⚠ NOL1/NOP2/sun family, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_004998	OG7
TcCLB.509805.40 ⚠ Multisite-specific tRNA:(cytosine-C(5))-methy	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_004998	OG7
TcCLB.508463.20 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000834 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_007258	OG7
TcCLB.511737.10 ⚠ small glutamine-rich tetratricopeptide repeat	—	OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_007258	OG7
TcCLB.509127.110 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_007258	OG7
TcCLB.511911.21 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007258	OG7
TcCLB.508723.100 ⚠ rab-like GTPase activating protein, putative	—	OG7 TCSYLVIO_004663 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004558 ↔ TCSYLVIO_004663	OG7

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