TcCLB.504137.10

isoleucyl-tRNA synthetase, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100811 OG7: OG7_0003029 175 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 175 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.504153.140 metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcCLB.506363.70 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
TcCLB.506363.90 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
TcCLB.511217.200 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
TcCLB.508321.50 ⚠ hypothetical protein, conserved	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
TcCLB.511049.40 leucyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004705	Both
TcCLB.511911.21 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcCLB.510777.20 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcCLB.509967.30 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcCLB.506363.80 ⚠ N-acyl-L-amino acid amidohydrolase, putative,	—	OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	OG7
TcCLB.510091.70 ⚠ U6 snRNA-associated Sm-like protein LSm8, put	—	OG7 LdBPK_354530.1 ↔ LdBPK_365870.1 OG7 LdBPK_301270.1 ↔ LdBPK_365870.1	OG7
TcCLB.510053.70 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_009102	Both
TcCLB.508089.30 N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010327	Both
TcCLB.510181.9 ⚠ inositol-3-phosphate synthase, putative (frag	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007453	Both
TcCLB.508539.30 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005125	Both
TcCLB.503589.10 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
TcCLB.506699.3 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004998	Both
TcCLB.511311.80 N-alpha-acetyltransferase 35, NatC auxiliary	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008986 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008986	Both
TcCLB.511181.90 peroxisome targeting signal 1 receptor, putat	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005361 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005361	Both
TcCLB.510963.39 PUB domain containing protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_009932	Both
TcCLB.509979.100 WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005180 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005180	Both
TcCLB.509247.50 methionyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007991	Both
TcCLB.506363.130 tRNA (Uracil-5-)-methyltransferase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008409 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008409	Both
TcCLB.458015.10 VHS domain containing protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008292 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008292	Both
TcCLB.510999.10 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005083 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005083	Both
TcCLB.507929.20 co-chaperone GrpE, putative	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_004705	Both
TcCLB.504625.80 hypothetical protein, conserved	—	OG6 LdBPK_050260.1 ↔ LdBPK_365870.1 OG7 LdBPK_050260.1 ↔ LdBPK_365870.1	Both
TcCLB.509757.30 ⚠ stress-inducible protein STI1-like, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004705	Both
TcCLB.511627.100 ⚠ TPR-repeat protein, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003496 ↔ TCSYLVIO_004705	Both
TcCLB.509551.64 ⚠ small nuclear ribonucleoprotein Sm-F, putativ	—	OG6 LdBPK_354530.1 ↔ LdBPK_365870.1 OG7 LdBPK_354530.1 ↔ LdBPK_365870.1 OG7 LdBPK_301270.1 ↔ LdBPK_365870.1	Both
TcCLB.510525.30 hypothetical protein, conserved	—	OG6 LdBPK_220710.1 ↔ LdBPK_365870.1 OG7 LdBPK_220710.1 ↔ LdBPK_365870.1	Both
TcCLB.506863.10 alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_004705	Both
TcCLB.509595.50 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	Both
TcCLB.507797.9 ⚠ nuclear transcription factor, putative	—	OG6 LdBPK_290620.1 ↔ LdBPK_365870.1 OG7 LdBPK_290620.1 ↔ LdBPK_365870.1	Both
TcCLB.429257.10 Gar1/Naf1 RNA binding region, putative	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_004705	Both
TcCLB.508181.140 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
TcCLB.503613.60 ⚠ acidocalcisomal pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
TcCLB.508241.120 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
TcCLB.511707.39 ⚠ Importin subunit beta-4, putative	—	OG7 LdBPK_070810.1 ↔ LdBPK_365870.1	OG7
TcCLB.506287.30 ⚠ cytochrome b5-like Heme/Steroid binding domai	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcCLB.506773.44 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcCLB.507047.160 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcCLB.506753.110 ⚠ cytochrome b5-like protein, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcCLB.504431.109 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcCLB.503653.60 ⚠ cytochrome b-domain protein, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcCLB.510231.20 hypothetical protein	—	OG7 LdBPK_250420.1 ↔ LdBPK_365870.1	OG7
TcCLB.510963.30 ⚠ cap guanine-N7 methyltransferase	—	OG7 LdBPK_220011.1 ↔ LdBPK_365870.1	OG7
TcCLB.506733.140 hypothetical protein, conserved	—	OG7 LdBPK_130770.1 ↔ LdBPK_365870.1	OG7
TcCLB.507639.110 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_332920.1 ↔ LdBPK_365870.1	OG7
TcCLB.510165.30 ⚠ R3H domain containing protein, putative	—	OG7 LdBPK_290620.1 ↔ LdBPK_365870.1	OG7

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