TcCLB.504427.110

acetyl-CoA synthetase, putative

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100430 OG7: OG7_0000501 43 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 43 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.447925.10 ⚠ cystathionine beta-synthase, putative (fragme	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128	OG6
TcCLB.511691.20 ⚠ cystathionine beta-synthase, cysteine synthas	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcCLB.511691.10 ⚠ cysteine synthase, cystathionine beta-synthas	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcCLB.510381.10 ⚠ cystathionine beta-synthase, putative	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcCLB.507165.50 ⚠ cysteine synthase, putative	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_008128	Both
TcCLB.508241.140 ⚠ serine sulfhydrylase, cysteine synthase, cyst	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcCLB.508241.149 ⚠ cystathionine beta-synthase, putative (fragme	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcCLB.509149.9 ⚠ cystathionine beta-synthase, serine sulfhydry	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcCLB.510751.4 ⚠ aminopeptidase P, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001380 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	Both
TcCLB.504427.10 ⚠ trypanothione synthetase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcCLB.510749.99 ⚠ aminopeptidase P, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001380 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	Both
TcCLB.509543.50 ⚠ DNAK protein, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
TcCLB.509137.30 ⚠ imidazolonepropionase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000878 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000878	Both
TcCLB.508813.15 ⚠ heat shock protein 70, putative (fragment)	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
TcCLB.508647.280 ⚠ malic enzyme	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
TcCLB.509099.30 paraflagellar rod protein 5, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000425 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	Both
TcCLB.509801.30 citrate synthase, putative	—	OG6 LdBPK_180700.1 ↔ LdBPK_230580.1 OG6 LdBPK_180700.1 ↔ LdBPK_230880.1 OG7 LdBPK_180700.1 ↔ LdBPK_230580.1 OG7 LdBPK_180700.1 ↔ LdBPK_230880.1	Both
TcCLB.507257.20 ⚠ NOL1/NOP2/sun family, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcCLB.509951.10 ⚠ nucleolar protein, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcCLB.506637.30 ⚠ Protein of unknown function (DUF3808), putati	—	OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	OG7
TcCLB.506467.29 ⚠ methyltransferase domain containing protein,	—	OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	OG7
TcCLB.510089.60 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcCLB.508771.20 ⚠ cysteine peptidase, Clan CA, family C51, puta	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcCLB.508771.10 ⚠ cysteine peptidase, Clan CA, family C51, puta	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcCLB.486465.9 ⚠ cysteine peptidase, Clan CA, family C51, puta	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcCLB.418069.10 ⚠ heat shock protein 70 (hsp70), putative (frag	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
TcCLB.507807.20 hypothetical protein, conserved	—	OG6 LdBPK_080930.1 ↔ LdBPK_230880.1 OG7 LdBPK_080930.1 ↔ LdBPK_230880.1	Both
TcCLB.511729.50 hypothetical protein, conserved	—	OG6 LdBPK_230880.1 ↔ LdBPK_303370.1 OG7 LdBPK_230880.1 ↔ LdBPK_303370.1	Both
TcCLB.507611.340 hypothetical protein, conserved	—	OG6 LdBPK_230580.1 ↔ LdBPK_367300.1 OG6 LdBPK_230880.1 ↔ LdBPK_367300.1 OG7 LdBPK_230580.1 ↔ LdBPK_367300.1 OG7 LdBPK_230880.1 ↔ LdBPK_367300.1	Both
TcCLB.506945.330 ⚠ Protein of unknown function (DUF3808), putati	—	OG6 LdBPK_230580.1 ↔ LdBPK_303750.1 OG6 LdBPK_230880.1 ↔ LdBPK_303750.1 OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	Both
TcCLB.504159.109 ⚠ NOL1/NOP2/sun family, putative	—	OG6 LdBPK_230580.1 ↔ LdBPK_322580.1 OG6 LdBPK_230880.1 ↔ LdBPK_322580.1 OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	Both
TcCLB.504143.10 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_230580.1 ↔ LdBPK_291030.1 OG6 LdBPK_230880.1 ↔ LdBPK_291030.1 OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	Both
TcCLB.503899.90 asparagine synthetase a, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002332 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002332	Both
TcCLB.441401.10 ⚠ imidazolonepropienase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000878 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000878	Both
TcCLB.509099.50 ⚠ trypanothione synthetase	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000427 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	Both
TcCLB.511559.20 Uncharacterised protein family (UPF0160), put	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_006555 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_006555	Both
TcCLB.506135.9 ⚠ heat shock 70 kDa protein, putative (fragment	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
TcCLB.508647.270 ⚠ malic enzyme, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
TcCLB.504431.100 guanine deaminase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_007737 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_007737	Both
TcCLB.511211.160 ⚠ heat shock protein 70 (hsp70), putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
TcCLB.506825.190 hypothetical protein	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001834 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001834	Both
TcCLB.511211.220 ⚠ heat shock protein 70, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6
TcCLB.511211.170 ⚠ heat shock protein 70 (hsp70), putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002194	OG6