TcCLB.509153.90

dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_101427 OG7: OG7_0003559 15 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 15 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.511469.100
2-oxoisovalerate dehydrogenase beta subunit,
— Both
TcCLB.506553.20 ⚠
bromodomain factor 2 protein
— Both
TcCLB.510565.11 ⚠
tyrosine aminotransferase, putative (fragment
— Both
TcCLB.508537.5 ⚠
tyrosine aminotransferase, putative (fragment
— Both
TcCLB.504153.160
Metallocarboxypeptidase 1
— Both
TcCLB.511051.70 ⚠
aminopeptidase, putative, metallo-peptidase,
— Both
TcCLB.503747.10 ⚠
glutamine aminotransferase, putative (fragmen
— Both
TcCLB.511531.50
glucosamine-6-phosphate isomerase, putative,
— Both
TcCLB.504431.100
guanine deaminase, putative
— Both
TcCLB.507993.390
pyruvate kinase 2, putative
— Both
TcCLB.508535.50 ⚠
tyrosine aminotransferase
— OG7
TcCLB.506529.90 ⚠
metallo-peptidase, clan MA(E), family M1, put
— OG7
TcCLB.503671.10 ⚠
Aminopeptidase M1, putative (fragment)
— OG7
TcCLB.510719.70 ⚠
bromodomain-containing protein 3
— OG7
TcCLB.510325.69 ⚠
Aminopeptidase M1, putative (fragment)
— OG7
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.