TcCLB.507993.390

pyruvate kinase 2, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100258 OG7: OG7_0002165 189 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 189 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.506795.44
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
TcCLB.508181.140 ⚠
inorganic pyrophosphatase, putative
— Both
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcCLB.510841.10 ⚠
Kinesin-13 4b, putative (fragment)
— OG7
TcCLB.510213.110 ⚠
NADH-dependent fumarate reductase, putative
— Both
TcCLB.506885.413 ⚠
glyceraldehyde-3-phosphate dehydrogenase, put
— Both
TcCLB.511579.9 ⚠
fatty acyl CoA syntetase 1, putative (fragmen
— Both
TcCLB.508277.110 ⚠
cAMP specific phosphodiesterase, putative
— Both
TcCLB.506367.10 ⚠
isovaleryl-coA dehydrogenase, putative (fragm
— Both
TcCLB.509153.90
dihydrofolate reductase-thymidylate synthase
— Both
TcCLB.511581.10 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcCLB.509829.20 ⚠
isovaleryl-coA dehydrogenase, putative
— Both
TcCLB.504431.100
guanine deaminase, putative
— Both
TcCLB.461165.16 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcCLB.506829.110 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcCLB.506943.50 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— Both
TcCLB.510215.10 ⚠
NADH-dependent fumarate reductase, putative
— Both
TcCLB.511581.20 ⚠
fatty acyl CoA syntetase 1 (fragment)
— Both
TcCLB.506829.100 ⚠
fatty acyl CoA syntetase 1, putative
— Both
TcCLB.510957.9 ⚠
calpain-like cysteine peptidase, putative
— OG6
TcCLB.508537.10 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcCLB.508277.100 ⚠
cAMP specific phosphodiesterase, putative
— Both
TcCLB.506563.190 ⚠
calpain-like cysteine peptidase, putative
— OG6
TcCLB.508277.160 ⚠
glutaminyl-tRNA synthetase, putative
— Both
TcCLB.503467.9 ⚠
NADH-dependent fumarate reductase, putative (
— Both
TcCLB.511751.180 ⚠
pseudouridine synthase A-like protein, putati
— Both
TcCLB.503841.80 ⚠
NADH-dependent fumarate reductase, putative
— Both
TcCLB.439653.10 ⚠
NADH-dependent fumarate reductase, putative
— OG6
TcCLB.510105.230 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcCLB.503855.40 ⚠
calpain-like cysteine peptidase, putative, cy
— OG6
TcCLB.511069.4 ⚠
transketolase, putative
— Both
TcCLB.511531.50
glucosamine-6-phosphate isomerase, putative,
— Both
TcCLB.506943.60 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— Both
TcCLB.506563.220 ⚠
calpain-like cysteine peptidase, putative, cy
— OG6
TcCLB.508535.10 ⚠
NADH-dependent fumarate reductase, putative
— Both
TcCLB.503575.50 ⚠
fatty acyl CoA synthetase, putative
— Both
TcCLB.506409.240 ⚠
glyceraldehyde 3-phosphate dehydrogenase, C-t
— Both
TcCLB.507559.80
deoxyribose-phosphate aldolase, putative
— Both
TcCLB.506405.10
phosphomannomutase-like protein, putative
— Both
TcCLB.506363.90 ⚠
amidohydrolase, putative
— Both
TcCLB.506363.70 ⚠
amidohydrolase, putative
— Both
TcCLB.510323.20
Flagellum attachment zone protein 19, putativ
— Both
TcCLB.511801.50
tRNA threonylcarbamoyl adenosine modification
— Both
TcCLB.511577.40
35 kDa cyclophilin, putative, rotamase, putat
— OG6
TcCLB.503893.60 ⚠
UBA/TS-N domain containing protein, putative
— Both
TcCLB.506895.40 ⚠
Kinesin-13 1, putative
— OG7
TcCLB.509589.30 ⚠
Kinesin-13 5, putative
— OG7
TcCLB.508921.30 ⚠
Kinesin-13 4, putative
— OG7
TcCLB.505123.28 ⚠
Kinesin-13 4, putative
— OG7
TcCLB.511801.14 ⚠
protein lipid droplet kinase (LDK)
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.