TcCLB.439653.10

NADH-dependent fumarate reductase, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_104311 OG7: OG7_0002437 123 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 123 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.507927.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.506025.50 ⚠
Vacuolar proton pump subunit B, putative
— OG6
TcCLB.506857.110 ⚠
Uncharacterised protein family UPF0066, putat
— OG6
TcCLB.511529.9 ⚠
Importin-beta N-terminal domain/HEAT-like rep
— OG6
TcCLB.507047.80 ⚠
zinc-finger protein ZPR1, putative
— OG6
TcCLB.507641.60 ⚠
aldehyde dehydrogenase, putative
— OG6
TcCLB.511309.60 ⚠
hypothetical protein, conserved
— OG6
TcCLB.503959.50 ⚠
hypothetical protein, conserved
— OG6
TcCLB.508717.40 ⚠
branch point binding protein, putative
— OG6
TcCLB.506773.20 ⚠
hypothetical protein, conserved
— OG6
TcCLB.506945.50 ⚠
T-complex protein 11, putative
— OG6
TcCLB.504137.10 ⚠
isoleucyl-tRNA synthetase, putative
— OG6
TcCLB.508469.59 ⚠
helicase, putative
— OG6
TcCLB.508207.230 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG6
TcCLB.506405.120 ⚠
V-type ATPase, A subunit, putative
— OG6
TcCLB.510101.140 ⚠
pyruvate phosphate dikinase, putative
— OG6
TcCLB.506221.70 ⚠
Paraflagellar Rod Proteome Component 9, putat
— OG6
TcCLB.506529.420 ⚠
glutamic--pyruvic transaminase, putative, ala
— OG6
TcCLB.418069.10 ⚠
heat shock protein 70 (hsp70), putative (frag
— OG6
TcCLB.506529.430 ⚠
alanine aminotransferase, putative, glutamic-
— OG6
TcCLB.506135.9 ⚠
heat shock 70 kDa protein, putative (fragment
— OG6
TcCLB.511211.160 ⚠
heat shock protein 70 (hsp70), putative
— OG6
TcCLB.511211.220 ⚠
heat shock protein 70, putative
— OG6
TcCLB.511211.170 ⚠
heat shock protein 70 (hsp70), putative
— OG6
TcCLB.509543.50 ⚠
DNAK protein, putative
— OG6
TcCLB.508813.15 ⚠
heat shock protein 70, putative (fragment)
— OG6
TcCLB.464807.20 ⚠
PA26 p53-induced protein (sestrin), putative
— OG6
TcCLB.511585.40 ⚠
DNA-damage inducible protein DDI1-like protei
— OG6
TcCLB.503885.90 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— OG6
TcCLB.503405.10 ⚠
glutamine synthetase
— OG6
TcCLB.506857.20 ⚠
pyrroline-5-carboxylate reductase, putative
— OG6
TcCLB.511693.10 ⚠
hypothetical protein
— OG6
TcCLB.507797.9 ⚠
nuclear transcription factor, putative
— OG6
TcCLB.511113.9 ⚠
hypothetical protein, conserved (fragment)
— OG6
TcCLB.508209.140 ⚠
protein disulfide isomerase, putative
— OG7
TcCLB.507611.370 ⚠
protein disulfide isomerase 2
— OG7
TcCLB.510227.29 ⚠
thioredoxin, putative (fragment)
— OG7
TcCLB.508647.200 ⚠
triosephosphate isomerase
— OG7
TcCLB.509199.24 ⚠
ribose 5-phosphate isomerase type B
— OG7
TcCLB.507883.100 ⚠
malate dehydrogenase, putative
— OG7
TcCLB.506503.69 ⚠
glycosomal malate dehydrogenase, putative
— OG7
TcCLB.507883.109 ⚠
mitochondrial malate dehydrogenase, putative
— OG7
TcCLB.511001.190 ⚠
vacuolar ATP synthase subunit d, putative
— OG6
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— OG6
TcCLB.508181.140 ⚠
inorganic pyrophosphatase, putative
— OG6
TcCLB.503689.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.508347.120 ⚠
hypothetical protein, conserved
— OG6
TcCLB.506859.70 ⚠
guide RNA associated protein, GAP2, putative
— OG6
TcCLB.507993.390 ⚠
pyruvate kinase 2, putative
— OG6
TcCLB.509967.30 ⚠
aspartyl-tRNA synthetase, putative
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.