TcCLB.506025.50

Vacuolar proton pump subunit B, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100544 OG7: OG7_0005088 98 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 98 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.503467.9 ⚠
NADH-dependent fumarate reductase, putative (
— +2 more Both
TcCLB.506405.120
V-type ATPase, A subunit, putative
— Both
TcCLB.511589.10
ATP synthase, putative
— Both
TcCLB.503841.80 ⚠
NADH-dependent fumarate reductase, putative
— +2 more Both
TcCLB.510213.110 ⚠
NADH-dependent fumarate reductase, putative
— +2 more Both
TcCLB.439653.10 ⚠
NADH-dependent fumarate reductase, putative
— OG6
TcCLB.508781.20
ATP synthase, putative
— Both
TcCLB.508535.10 ⚠
NADH-dependent fumarate reductase, putative
— +2 more Both
TcCLB.510215.10 ⚠
NADH-dependent fumarate reductase, putative
— +2 more Both
TcCLB.511067.10
tubulin folding cofactor D, putative
— Both
TcCLB.509351.10
delta-1-pyrroline-5-carboxylate dehydrogenase
— Both
TcCLB.506529.516
ATP synthase subunit, putative
— Both
TcCLB.506857.110
Uncharacterised protein family UPF0066, putat
— Both
TcCLB.508951.20
hexokinase, putative
— Both
TcCLB.509537.80 ⚠
TPR repeat, putative
— OG7
TcCLB.506859.70
guide RNA associated protein, GAP2, putative
— Both
TcCLB.510963.50 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
TcCLB.508369.50 ⚠
acetyl-CoA carboxylase (fragment)
— Both
TcCLB.503449.30
clathrin coat assembly protein, putative
— Both
TcCLB.511145.60
ATP synthase F1 subunit gamma protein, putati
— Both
TcCLB.509233.180
ATP synthase subunit beta, mitochondrial, put
— Both
TcCLB.511589.200
S-adenosylhomocysteine hydrolase, putative
— Both
TcCLB.510101.140
pyruvate phosphate dikinase, putative
— Both
TcCLB.503777.19 ⚠
phosphoribosylpyrophosphate synthetase, putat
— +1 more Both
TcCLB.510599.14 ⚠
acetyl-CoA carboxylase (fragment)
— Both
TcCLB.507809.30 ⚠
ribose-phosphate pyrophosphokinase, putative
— +1 more Both
TcCLB.506375.110
(H+)-ATPase G subunit, putative
— Both
TcCLB.506607.19 ⚠
phosphoribosylpyrophosphate synthetase, putat
— +1 more Both
TcCLB.506945.240
ATP synthase, epsilon chain, putative
— Both
TcCLB.508717.30 ⚠
phosphoribosylpyrophosphate synthetase, putat
— +2 more Both
TcCLB.503893.140 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.427247.10 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.508675.9 ⚠
CMGC/DYRK protein kinase, putative (fragment)
— OG7
TcCLB.511353.40 ⚠
eukaryotic translation initiation factor 4E (
— OG7
TcCLB.506519.60 ⚠
CMGC/CLK family protein kinase, putative
— OG7
TcCLB.503479.70 ⚠
hook complex protein, conserved
— OG7
TcCLB.509757.20 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcCLB.508387.30 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.506739.190 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcCLB.504203.50 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcCLB.480785.10 ⚠
serine/threonine kinase, putative, CMGC/DYRK
— OG7
TcCLB.421959.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.509757.30 ⚠
stress-inducible protein STI1-like, putative
— OG7
TcCLB.506127.170 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
TcCLB.503579.110 ⚠
pseudouridylate synthase I, putative
— OG7
TcCLB.504935.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.511751.180 ⚠
pseudouridine synthase A-like protein, putati
— OG7
TcCLB.510431.140 ⚠
dual specificity tyrosine-phosphorylation-reg
— OG7
TcCLB.510777.29 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.511737.10 ⚠
small glutamine-rich tetratricopeptide repeat
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.