TcCLB.506795.44

Bifunctional NAD(P)H-hydrate repair enzyme
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100751 OG7: OG7_0006318 146 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 146 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.507993.390
pyruvate kinase 2, putative
— Both
TcCLB.507993.60 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506525.80
N-myristoyl transferase, putative
— Both
TcCLB.507993.150
Activator of Hsp90 ATPase, N-terminal/Activat
— Both
TcCLB.506931.10 ⚠
haloacid dehalogenase-like hydrolase, putativ
— Both
TcCLB.511741.40
RNA-binding protein, putative
— OG6
TcCLB.503841.70
aspartate aminotransferase, putative
— Both
TcCLB.506747.20 ⚠
dihydroorotase, putative
— Both
TcCLB.509955.10 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— Both
TcCLB.508373.20 ⚠
dihydroorotase, putative
— Both
TcCLB.509953.9 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— Both
TcCLB.511115.40 ⚠
transcription elongation factor s-II, putativ
— Both
TcCLB.511751.200
epsilon-adaptin, putative, AP-1/4 adapter com
— Both
TcCLB.507809.60
hypothetical protein, conserved
— Both
TcCLB.506405.10
phosphomannomutase-like protein, putative
— Both
TcCLB.506359.60
UTP-glucose-1-phosphate uridylyltransferase 2
— Both
TcCLB.507603.30
PITH domain-containing protein
— Both
TcCLB.509757.30 ⚠
stress-inducible protein STI1-like, putative
— Both
TcCLB.511627.100 ⚠
TPR-repeat protein, putative
— Both
TcCLB.506677.39 ⚠
Elongation factor G1, mitochondrial, putative
— Both
TcCLB.506363.90 ⚠
amidohydrolase, putative
— Both
TcCLB.510323.20
Flagellum attachment zone protein 19, putativ
— Both
TcCLB.506363.70 ⚠
amidohydrolase, putative
— Both
TcCLB.511801.50
tRNA threonylcarbamoyl adenosine modification
— Both
TcCLB.511577.40
35 kDa cyclophilin, putative, rotamase, putat
— OG6
TcCLB.503893.60 ⚠
UBA/TS-N domain containing protein, putative
— Both
TcCLB.508181.140 ⚠
inorganic pyrophosphatase, putative
— Both
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcCLB.510525.10 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcCLB.506895.40 ⚠
Kinesin-13 1, putative
— OG7
TcCLB.510257.130 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcCLB.511801.14 ⚠
protein lipid droplet kinase (LDK)
— OG7
TcCLB.509589.30 ⚠
Kinesin-13 5, putative
— OG7
TcCLB.511001.60 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcCLB.506493.50 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
TcCLB.508921.30 ⚠
Kinesin-13 4, putative
— OG7
TcCLB.505123.28 ⚠
Kinesin-13 4, putative
— OG7
TcCLB.510841.10 ⚠
Kinesin-13 4b, putative (fragment)
— OG7
TcCLB.421959.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.506659.39 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506925.150 ⚠
protein phosphatase 2C, putative
— OG7
TcCLB.506739.200 ⚠
pyruvate dehydrogenase phosphatase
— OG7
TcCLB.504153.140
metallo-peptidase, Clan MF, Family M17
— OG7
TcCLB.503959.50 ⚠
hypothetical protein, conserved
— OG7
TcCLB.503579.110 ⚠
pseudouridylate synthase I, putative
— OG7
TcCLB.510777.29 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.504935.10 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcCLB.511577.30 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506363.80 ⚠
N-acyl-L-amino acid amidohydrolase, putative,
— OG7
TcCLB.506495.3 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.