TcIL3000_10_2190

mitochondrial malate dehydrogenase
Trypanosoma congolense IL3000 OG6: OG6_101212 OG7: OG7_0004751 73 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 73 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcIL3000_9_2680 ⚠
spermidine synthase
— Both
TcIL3000.11.15610 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
TcIL3000_4_770 ⚠
ruvB-like DNA helicase, putative
— OG7
TcIL3000_0_52640 ⚠
cytochrome oxidase subunit V
— OG7
TcIL3000.11.3700 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
TcIL3000.11.9130 ⚠
glutathionylspermidine synthetase, putative
— OG7
TcIL3000.11.1240 ⚠
Oxidoreductase NAD-binding domain containing
— OG7
TcIL3000_0_44680 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcIL3000_0_59370 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
TcIL3000.11.7570 ⚠
NADH-cytochrome b5 reductase-like protein
— OG7
TcIL3000_0_44670 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcIL3000_0_08640 ⚠
NADH-cytochrome b5 reductase, putative
— OG7
TcIL3000_6_3500 ⚠
chaperonin HSP60, mitochondrial precursor, pu
— OG7
TcIL3000_5_2370 ⚠
sodium/hydrogen exchanger, putative
— Both
TcIL3000_0_07180 ⚠
sodium/hydrogen exchanger, putative
— Both
TcIL3000_1_1430 ⚠
amidohydrolase, putative
— Both
TcIL3000_10_8870 ⚠
trypanothione reductase, putative
— Both
TcIL3000_0_58210 ⚠
hypothetical protein (fragment)
— Both
TcIL3000_0_35790 ⚠
oligopeptidase b
— Both
TcIL3000_8_8210 ⚠
diadenosine tetraphosphatase, putative
— OG7
TcIL3000_5_1680 ⚠
Ecotin-like protein
— OG7
TcIL3000_0_25700 ⚠
inhibitor of serine peptidase (ISP), putative
— OG7
TcIL3000_0_08210 ⚠
ecotin, putative
— OG7
TcIL3000_0_08890 ⚠
inhibitor of serine peptidase (ISP), putative
— OG7
TcIL3000_3_3300 ⚠
FHA domain containing protein, putative
— OG7
TcIL3000_10_6730 ⚠
hypothetical protein, conserved
— OG7
TcIL3000_4_3670 ⚠
kinetoplastid-specific phospho-protein phosph
— OG7
TcIL3000_0_57160 ⚠
kinetoplastid-specific phospho-protein phosph
— OG7
TcIL3000_10_12660 ⚠
metallo-peptidase, Clan MG, Family M24
— Both
TcIL3000_8_8080 ⚠
kinetoplastid-specific phospho-protein phosph
— OG7
TcIL3000_10_3320 ⚠
ATP-dependent DEAD-box RNA helicase, putative
— OG7
TcIL3000_9_1560 ⚠
eukaryotic initiation factor 4a, putative
— OG7
TcIL3000.11.9080 ⚠
ATP-dependent RNA helicase FAL1, putative
— OG7
TcIL3000_10_8540 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
TcIL3000.11.4240 ⚠
Metallopeptidase family M24, putative
— OG7
TcIL3000_10_6890 ⚠
prolyl endopeptidase
— OG7
TcIL3000_5_4750 ⚠
prolyl oligopeptidase, putative
— OG7
TcIL3000_7_3590 ⚠
threonine synthase, putative
— Both
TcIL3000_10_6810 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
TcIL3000_10_5580 ⚠
chaperonin HSP60, mitochondrial precursor
— Both
TcIL3000_2_770 ⚠
trypanothione synthetase
— Both
TcIL3000_3_1870 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— Both
TcIL3000_0_27380 ⚠
NADH-cytochrome b5 reductase, putative
— Both
TcIL3000_10_6380 ⚠
succinyl-CoA ligase [GDP-forming] beta-chain,
— Both
TcIL3000.11.11900 ⚠
cytosolic malate dehydrogenase
— Both
TcIL3000_7_2050 ⚠
NADH-cytochrome b5 reductase, putative
— Both
TcIL3000_0_26910 ⚠
trypanothione synthetase, putative (fragment)
— Both
TcIL3000_7_10 ⚠
thimet oligopeptidase, putative
— Both
TcIL3000_0_00410 ⚠
Present in the outer mitochondrial membrane p
— Both
TcIL3000_6_1890 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.