TcIL3000_6_120

ccr4-not transcription complex subunit
Trypanosoma congolense IL3000 OG6: OG6_101138 OG7: OG7_0005422 182 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 182 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcIL3000_8_1990
hypothetical protein, conserved
— Both
TcIL3000_10_1310
CCR4-NOT transcription complex subunit 1
— Both
TcIL3000_3_1020
General negative regulator of transcription s
— Both
TcIL3000_4_90
cell differentiation protein, putative
— Both
TcIL3000_6_390
ccr4-not transcription complex subunit 2
— Both
TcIL3000_8_5040 ⚠
cullin, putative
— OG7
TcIL3000_6_1180 ⚠
cell division cycle protein 16 homolog, putat
— Both
TcIL3000.11.8410 ⚠
DNA replication licensing factor MCM2, putati
— OG6
TcIL3000.11.11300 ⚠
Adaptor protein complex AP-3 subunit beta-3
— Both
TcIL3000_10_4530
intraflagellar transport protein 122, putativ
— Both
TcIL3000_10_12370
intraflagellar transport protein 140, putativ
— Both
TcIL3000_4_4300 ⚠
dihydrolipoamide dehydrogenase, putative
— Both
TcIL3000_0_24690 ⚠
Rab3 GTPase-activating protein catalytic subu
— Both
TcIL3000.11.620 ⚠
RNA polymerase I second largest subunit (frag
— Both
TcIL3000_6_180
hypothetical protein, conserved
— Both
TcIL3000_4_1910 ⚠
hypothetical protein, conserved
— OG6
TcIL3000_7_3400 ⚠
WD domain, G-beta repeat/Dip2/Utp12 Family, p
— Both
TcIL3000_1_1600 ⚠
TPR repeat, putative
— Both
TcIL3000_7_4730
hypothetical protein, conserved (fragment)
— Both
TcIL3000_0_41520 ⚠
tubulin tyrosine ligase, putative (fragment)
— Both
TcIL3000_5_4350 ⚠
tubulin tyrosine ligase, putative
— Both
TcIL3000_0_55630 ⚠
RNA-binding protein, putative
— Both
TcIL3000_6_3010 ⚠
RNA-binding protein, putative (fragment)
— Both
TcIL3000.11.13720
AAA ATPase, putative
— Both
TcIL3000_3_1800 ⚠
hypothetical protein, conserved
— Both
TcIL3000_7_5570 ⚠
Phosphatidylinositol 4-phosphate 5-kinase, pu
— OG7
TcIL3000_4_1950 ⚠
Sec7 domain containing protein, putative
— OG7
TcIL3000_0_38710 ⚠
ubiquitin-protein ligase, putative
— OG7
TcIL3000_8_5130 ⚠
WW domain containing protein, putative
— OG7
TcIL3000_6_1870 ⚠
ubiquitin-protein ligase, putative
— OG7
TcIL3000_0_55120 ⚠
hypothetical protein
— OG7
TcIL3000_0_11960 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
TcIL3000_0_25450 ⚠
SPRY domain containing protein, putative (fra
— OG7
TcIL3000_6_2060 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcIL3000_10_8790 ⚠
Anaphase-promoting complex, cyclosome, subuni
— OG7
TcIL3000_1_900 ⚠
tubulin-tyrosine ligase, putative
— OG7
TcIL3000_10_11810 ⚠
tubulin tyrosine ligase protein, putative
— OG7
TcIL3000_0_10970 ⚠
Tubulin-tyrosine ligase family, putative (fra
— OG7
TcIL3000.11.7370 ⚠
tubulin-tyrsoine ligase-like protein, putativ
— OG7
TcIL3000_3_3320 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
TcIL3000_9_3430 ⚠
tubulin tyrosine ligase protein, putative
— OG7
TcIL3000_0_21510 ⚠
tubulin-tyrsoine ligase-like protein, putativ
— OG7
TcIL3000_2_1360 ⚠
tubulin-tyrosine ligase, putative
— OG7
TcIL3000_0_07290 ⚠
paraflagellar rod component, putative
— OG7
TcIL3000_0_03450 ⚠
dihydrolipoamide dehydrogenase, point mutatio
— OG7
TcIL3000.11.14950 ⚠
Phosphatidylinositol 3- and 4-kinase/FATC dom
— OG7
TcIL3000_0_02690 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
TcIL3000_10_6910 ⚠
beta adaptin, putative
— OG7
TcIL3000_0_22010 ⚠
cullin 1, putative
— OG7
TcIL3000_0_01730 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.