TcYC6_0031310

acetyl-CoA synthetase, putative

Trypanosoma cruzi Y C6 OG6: OG6_100430 OG7: OG7_0000501 44 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 44 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0044910 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0044880 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0006570 ⚠ cysteine synthase, putative	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_008128	Both
TcYC6_0128170 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0044870 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0044900 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0046320 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0044890 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0175670 ⚠ hypothetical protein	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0044440 ⚠ serine sulfhydrylase	—	OG6 LdBPK_170300.1 ↔ LdBPK_230580.1 OG6 LdBPK_170300.1 ↔ LdBPK_230880.1 OG6 TCSYLVIO_000046 ↔ TCSYLVIO_008128 OG7 LdBPK_170300.1 ↔ LdBPK_230580.1 +1 more	Both
TcYC6_0109070 guanine deaminase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_007737 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_007737	Both
TcYC6_0110020 ⚠ paraflagellar rod protein 3, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
TcYC6_0068430 metallo-peptidase, Clan MG, Family M24, putat	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001380 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001380	Both
TcYC6_0107640 ⚠ nucleolar protein, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcYC6_0014080 ⚠ NOL1/NOP2/sun family, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcYC6_0110330 ⚠ NOL1/NOP2/sun family, putative	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcYC6_0119100 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	OG7
TcYC6_0086100 ⚠ methyltransferase domain containing protein,	—	OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	OG7
TcYC6_0088810 ⚠ Protein of unknown function (DUF3808), putati	—	OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	OG7
TcYC6_0120660 ⚠ glutathionylspermidine synthase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcYC6_0110000 ⚠ paraflagellar rod protein 3, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
TcYC6_0077360 ⚠ cysteine peptidase, Clan CA, family C51, puta	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcYC6_0077370 ⚠ cysteine peptidase, Clan CA, family C51, puta	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcYC6_0031400 ⚠ trypanothione synthetase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcYC6_0109980 ⚠ paraflagellar rod protein 3, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
TcYC6_0120330 ⚠ glutathionylspermidine synthase, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	OG7
TcYC6_0110010 ⚠ paraflagellar rod protein 3, putative	—	OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	OG7
TcYC6_0115870 citrate synthase, putative	—	OG6 LdBPK_180700.1 ↔ LdBPK_230580.1 OG6 LdBPK_180700.1 ↔ LdBPK_230880.1 OG7 LdBPK_180700.1 ↔ LdBPK_230580.1 OG7 LdBPK_180700.1 ↔ LdBPK_230880.1	Both
TcYC6_0065530 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_080930.1 ↔ LdBPK_230880.1 OG7 LdBPK_080930.1 ↔ LdBPK_230880.1	Both
TcYC6_0004850 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_080930.1 ↔ LdBPK_230880.1 OG7 LdBPK_080930.1 ↔ LdBPK_230880.1	Both
TcYC6_0098700 hypothetical protein, conserved	—	OG6 LdBPK_230880.1 ↔ LdBPK_303370.1 OG7 LdBPK_230880.1 ↔ LdBPK_303370.1	Both
TcYC6_0099060 ⚠ hypothetical protein	—	OG6 LdBPK_230580.1 ↔ LdBPK_303750.1 OG6 LdBPK_230880.1 ↔ LdBPK_303750.1 OG7 LdBPK_230580.1 ↔ LdBPK_303750.1 OG7 LdBPK_230880.1 ↔ LdBPK_303750.1	Both
TcYC6_0121150 hypothetical protein, conserved	—	OG6 LdBPK_230580.1 ↔ LdBPK_367300.1 OG6 LdBPK_230880.1 ↔ LdBPK_367300.1 OG7 LdBPK_230580.1 ↔ LdBPK_367300.1 OG7 LdBPK_230880.1 ↔ LdBPK_367300.1	Both
TcYC6_0051270 ⚠ NOL1/NOP2/sun family, putative	—	OG6 LdBPK_230580.1 ↔ LdBPK_322580.1 OG6 LdBPK_230880.1 ↔ LdBPK_322580.1 OG7 LdBPK_230580.1 ↔ LdBPK_322580.1 OG7 LdBPK_230880.1 ↔ LdBPK_322580.1	Both
TcYC6_0070280 kinetoplastid kinetochore protein 3, putative	—	OG6 LdBPK_230880.1 ↔ LdBPK_354110.1 OG7 LdBPK_230880.1 ↔ LdBPK_354110.1	Both
TcYC6_0109280 ⚠ 5-histidylcysteine sulfoxide synthase	—	OG6 LdBPK_230580.1 ↔ LdBPK_291030.1 OG6 LdBPK_230880.1 ↔ LdBPK_291030.1 OG7 LdBPK_230580.1 ↔ LdBPK_291030.1 OG7 LdBPK_230880.1 ↔ LdBPK_291030.1	Both
TcYC6_0076480 ⚠ paraflagellar rod protein	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000425 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000425	Both
TcYC6_0058320 asparagine synthetase a, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_002332 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_002332	Both
TcYC6_0046060 hypothetical protein	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001834 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001834	Both
TcYC6_0081680 ⚠ malic enzyme, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
TcYC6_0037100 Uncharacterised protein family (UPF0160), put	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_006555 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_006555	Both
TcYC6_0000710 imidazolonepropionase, putative	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000878 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000878	Both
TcYC6_0081690 ⚠ malic enzyme	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_001501 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_001501	Both
TcYC6_0076460 ⚠ trypanothione synthetase	—	OG6 TCSYLVIO_000046 ↔ TCSYLVIO_000427 OG7 TCSYLVIO_000046 ↔ TCSYLVIO_000427	Both