TcYC6_0081690

malic enzyme
Trypanosoma cruzi Y C6 OG6: OG6_100205 OG7: OG7_0002857 62 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 62 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0077360 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcYC6_0046320 ⚠
serine sulfhydrylase
— OG6
TcYC6_0044900 ⚠
serine sulfhydrylase
— OG6
TcYC6_0044870 ⚠
serine sulfhydrylase
— OG6
TcYC6_0037100 ⚠
Uncharacterised protein family (UPF0160), put
— Both
TcYC6_0128170 ⚠
serine sulfhydrylase
— OG6
TcYC6_0006570 ⚠
cysteine synthase, putative
— Both
TcYC6_0109070 ⚠
guanine deaminase, putative
— Both
TcYC6_0124530 ⚠
ATP-binding cassette sub-family F member 1, p
— Both
TcYC6_0103830 ⚠
peptidase, putative
— Both
TcYC6_0031310 ⚠
acetyl-CoA synthetase, putative
— Both
TcYC6_0121550 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
TcYC6_0076460 ⚠
trypanothione synthetase
— Both
TcYC6_0025370 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0043810 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
TcYC6_0120660 ⚠
glutathionylspermidine synthase, putative
— OG7
TcYC6_0046060 ⚠
hypothetical protein
— Both
TcYC6_0120330 ⚠
glutathionylspermidine synthase, putative
— OG7
TcYC6_0077370 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
TcYC6_0031400 ⚠
trypanothione synthetase, putative
— OG7
TcYC6_0110000 ⚠
paraflagellar rod protein 3, putative
— OG7
TcYC6_0109980 ⚠
paraflagellar rod protein 3, putative
— OG7
TcYC6_0110010 ⚠
paraflagellar rod protein 3, putative
— OG7
TcYC6_0110020 ⚠
paraflagellar rod protein 3, putative
— OG7
TcYC6_0119810 ⚠
translation elongation factor EF-2, putative
— OG7
TcYC6_0051670 ⚠
small nuclear ribonucleoprotein component
— OG7
TcYC6_0004090 ⚠
ABC transporter, putative
— OG7
TcYC6_0113630 ⚠
ABC transport system ATP-binding protein, put
— OG7
TcYC6_0024170 ⚠
ABC transporter, putative
— OG7
TcYC6_0029650 ⚠
ABC transporter, putative
— OG7
TcYC6_0002740 ⚠
ABC transporter, putative
— OG7
TcYC6_0080670 ⚠
elongation factor 2
— Both
TcYC6_0069460 ⚠
6-phosphogluconate dehydrogenase, decarboxyla
— Both
TcYC6_0074780 ⚠
isocitrate dehydrogenase, putative
— +2 more Both
TcYC6_0115870 ⚠
citrate synthase, putative
— Both
TcYC6_0110280 ⚠
Fumarate hydratase class I, cytosolic
— Both
TcYC6_0063070 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— +2 more Both
TcYC6_0081230 ⚠
fumarate hydratase, putative
— Both
TcYC6_0120070 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
TcYC6_0112370 ⚠
enolase
— Both
TcYC6_0068430 ⚠
metallo-peptidase, Clan MG, Family M24, putat
— Both
TcYC6_0000710 ⚠
imidazolonepropionase, putative
— Both
TcYC6_0076480 ⚠
paraflagellar rod protein
— Both
TcYC6_0080650 ⚠
elongation factor 2
— Both
TcYC6_0080630 ⚠
elongation factor 2
— Both
TcYC6_0080620 ⚠
elongation factor 2
— Both
TcYC6_0080640 ⚠
elongation factor 2
— Both
TcYC6_0081680 ⚠
malic enzyme, putative
— Both
TcYC6_0080610 ⚠
elongation factor 2
— Both
TcYC6_0080660 ⚠
elongation factor 2
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.