TcYC6_0074780

isocitrate dehydrogenase, putative
Trypanosoma cruzi Y C6 OG6: OG6_100639 OG7: OG7_0004251 194 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 194 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0116190 ⚠
UTP-glucose-1-phosphate uridylyltransferase 2
— Both
TcYC6_0047030 ⚠
aspartate aminotransferase, putative
— Both
TcYC6_0049770 ⚠
enoyl-CoA hydratase/isomerase family protein,
— Both
TcYC6_0049760 ⚠
enoyl-CoA hydratase/isomerase family protein,
— Both
TcYC6_0007780 ⚠
NUDIX hydrolase 3, putative
— Both
TcYC6_0088930 ⚠
pyroglutamyl-peptidase I, putative
— Both
TcYC6_0063100 ⚠
putative protein transport protein SEC23
— Both
TcYC6_0005460 ⚠
CHORD, putative
— Both
TcYC6_0053430 ⚠
Alpha/beta hydrolase family, putative
— Both
TcYC6_0096570 ⚠
epsilon-adaptin, putative
— Both
TcYC6_0089640 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0091050 ⚠
phosphomannomutase-like protein, putative
— Both
TcYC6_0089650 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0007710 ⚠
Biotin--acetyl-CoA-carboxylase ligase, putati
— Both
TcYC6_0075790 ⚠
TPR-repeat protein, putative
— OG6
TcYC6_0080780 ⚠
stress-inducible protein STI1-like, putative
— OG6
TcYC6_0080140 ⚠
Elongation factor G1, mitochondrial, putative
— Both
TcYC6_0109610 ⚠
carnitine/choline acetyltransferase, putative
— Both
TcYC6_0050610 ⚠
Nucleoside diphosphate kinase 1
— Both
TcYC6_0110890 ⚠
Flagellum attachment zone protein 19, putativ
— Both
TcYC6_0012390 ⚠
tRNA threonylcarbamoyl adenosine modification
— Both
TcYC6_0119740 ⚠
hypothetical protein, conserved
— Both
TcYC6_0084720 ⚠
rotamase, putative
— OG6
TcYC6_0051940 ⚠
hypothetical protein, conserved
— Both
TcYC6_0045140 ⚠
Component of motile flagella 15
— Both
TcYC6_0080210 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0045150 ⚠
electron-transfer-flavoprotein, alpha polypep
— Both
TcYC6_0092460 ⚠
SEP domain containing protein, putative
— Both
TcYC6_0030300 ⚠
alanine racemase, putative
— Both
TcYC6_0075930 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0052500 ⚠
protein phosphatase 2C
— OG6
TcYC6_0062480 ⚠
putative choline/ethanolamine kinase
— Both
TcYC6_0062450 ⚠
putative choline/ethanolamine kinase
— Both
TcYC6_0123640 ⚠
mitochondrial intermediate peptidase, putativ
— Both
TcYC6_0016600 ⚠
Mitochondrial Editosome-like Complex TUTase
— Both
TcYC6_0010170 ⚠
hypothetical protein, conserved
— Both
TcYC6_0074380 ⚠
UBA/TS-N domain containing protein, putative
— Both
TcYC6_0044260 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0115010 ⚠
N-myristoyl transferase, putative
— Both
TcYC6_0066530 ⚠
dihydroorotase, putative
— Both
TcYC6_0115920 ⚠
alcohol dehydrogenase, putative
— Both
TcYC6_0107700 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— Both
TcYC6_0054750 ⚠
dihydroorotase, putative
— Both
TcYC6_0017390 ⚠
cytidine triphosphate synthase, putative
— Both
TcYC6_0125230 ⚠
nicotinate phosphoribosyltransferase, putativ
— Both
TcYC6_0077340 ⚠
transcription elongation factor-like protein,
— Both
TcYC6_0065780 ⚠
hypothetical protein, conserved
— Both
TcYC6_0119320 ⚠
hypothetical protein, conserved
— Both
TcYC6_0036070 ⚠
ATP-dependent protease ATPase subunit HslU2
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.