TcYC6_0088930

pyroglutamyl-peptidase I, putative
Trypanosoma cruzi Y C6 OG6: OG6_101530 OG7: OG7_0006024 165 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 165 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0055760
hypothetical protein, conserved
— Both
TcYC6_0061710
PITH domain-containing protein
— Both
TcYC6_0074780 ⚠
isocitrate dehydrogenase, putative
— Both
TcYC6_0063070 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— Both
TcYC6_0053430
Alpha/beta hydrolase family, putative
— Both
TcYC6_0096570 ⚠
epsilon-adaptin, putative
— Both
TcYC6_0091050
phosphomannomutase-like protein, putative
— Both
TcYC6_0007710
Biotin--acetyl-CoA-carboxylase ligase, putati
— Both
TcYC6_0075790 ⚠
TPR-repeat protein, putative
— OG6
TcYC6_0080780 ⚠
stress-inducible protein STI1-like, putative
— OG6
TcYC6_0080140 ⚠
Elongation factor G1, mitochondrial, putative
— Both
TcYC6_0109610 ⚠
carnitine/choline acetyltransferase, putative
— Both
TcYC6_0110890
Flagellum attachment zone protein 19, putativ
— Both
TcYC6_0012390
tRNA threonylcarbamoyl adenosine modification
— Both
TcYC6_0119740
hypothetical protein, conserved
— Both
TcYC6_0084720
rotamase, putative
— OG6
TcYC6_0051940 ⚠
hypothetical protein, conserved
— Both
TcYC6_0045140
Component of motile flagella 15
— Both
TcYC6_0009670
hexokinase, putative
— Both
TcYC6_0006190
ATP-dependent protease subunit HslV, putative
— Both
TcYC6_0080210 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0095140 ⚠
phosphatase 2C, putative
— OG6
TcYC6_0045150
electron-transfer-flavoprotein, alpha polypep
— Both
TcYC6_0030300
alanine racemase, putative
— Both
TcYC6_0092460
SEP domain containing protein, putative
— Both
TcYC6_0075930 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0045720 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0052500 ⚠
protein phosphatase 2C
— OG6
TcYC6_0120070
succinyl-CoA synthetase alpha subunit, putati
— Both
TcYC6_0016600 ⚠
Mitochondrial Editosome-like Complex TUTase
— Both
TcYC6_0010170 ⚠
hypothetical protein, conserved
— Both
TcYC6_0074380 ⚠
UBA/TS-N domain containing protein, putative
— Both
TcYC6_0044260 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0115010
N-myristoyl transferase, putative
— Both
TcYC6_0066530 ⚠
dihydroorotase, putative
— Both
TcYC6_0107700
ubiquitin carboxyl-terminal hydrolase, putati
— Both
TcYC6_0054750 ⚠
dihydroorotase, putative
— Both
TcYC6_0125230
nicotinate phosphoribosyltransferase, putativ
— Both
TcYC6_0077340 ⚠
transcription elongation factor-like protein,
— Both
TcYC6_0045560
deoxyribose-phosphate aldolase, putative
— Both
TcYC6_0065780
hypothetical protein, conserved
— Both
TcYC6_0117550 ⚠
NAD binding domain of 6-phosphogluconate dehy
— OG7
TcYC6_0104220 ⚠
hypothetical protein
— OG7
TcYC6_0146170 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0142880 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0142810 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0085450 ⚠
monothiol glutaredoxin, putative
— OG7
TcYC6_0012100 ⚠
elongation factor G2-like protein, putative
— OG7
TcYC6_0044720 ⚠
haloacid dehalogenase hydrolase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.