TcYC6_0061710

PITH domain-containing protein
Trypanosoma cruzi Y C6 OG6: OG6_102988 OG7: OG7_0006444 198 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 198 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0044720 ⚠
haloacid dehalogenase hydrolase, putative
— OG7
TcYC6_0012960 ⚠
haloacid dehalogenase-like hydrolase, putativ
— +1 more Both
TcYC6_0012930 ⚠
haloacid dehalogenase-like hydrolase, putativ
— +1 more Both
TcYC6_0122380
Sucrase/ferredoxin-like, putative
— Both
TcYC6_0007710
Biotin--acetyl-CoA-carboxylase ligase, putati
— Both
TcYC6_0050860 ⚠
iron superoxide dismutase, putative
— Both
TcYC6_0050990 ⚠
superoxide dismutase, putative
— Both
TcYC6_0080780 ⚠
stress-inducible protein STI1-like, putative
— OG6
TcYC6_0065780
hypothetical protein, conserved
— Both
TcYC6_0052370 ⚠
iron superoxide dismutase, putative
— Both
TcYC6_0032120 ⚠
hypothetical protein, conserved
— Both
TcYC6_0075790 ⚠
TPR-repeat protein, putative
— OG6
TcYC6_0115830 ⚠
CAMK/CAMKL family protein kinase, putative
— Both
TcYC6_0054750 ⚠
dihydroorotase, putative
— Both
TcYC6_0019440
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
TcYC6_0008340
phosphoenolpyruvate mutase, putative
— Both
TcYC6_0054200
6-phosphogluconolactonase, putative
— Both
TcYC6_0108610
U-box domain protein, putative
— Both
TcYC6_0065990 ⚠
iron superoxide dismutase A, mitochondrial
— Both
TcYC6_0079840
eukaryotic translation initiation factor 6 (e
— Both
TcYC6_0016600 ⚠
Mitochondrial Editosome-like Complex TUTase
— Both
TcYC6_0100460 ⚠
CAMK/CAMKL family protein kinase, putative
— Both
TcYC6_0062990
Mitogen-activated protein kinase 10, putative
— OG6
TcYC6_0175660 ⚠
monothiol glutaredoxin, putative
— Both
TcYC6_0075930 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0049100
Macro domain containing protein, putative
— Both
TcYC6_0063760
mitogen-activated protein kinase 3, putative
— OG6
TcYC6_0076050 ⚠
esterase, putative
— Both
TcYC6_0024610 ⚠
hypothetical protein
— Both
TcYC6_0067090
2OG-Fe(II) oxygenase superfamily, putative
— Both
TcYC6_0010170 ⚠
hypothetical protein, conserved
— Both
TcYC6_0112320
Soluble NSF attachment protein, SNAP, putativ
— Both
TcYC6_0074380 ⚠
UBA/TS-N domain containing protein, putative
— Both
TcYC6_0044260 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0115010
N-myristoyl transferase, putative
— Both
TcYC6_0107700
ubiquitin carboxyl-terminal hydrolase, putati
— Both
TcYC6_0125230
nicotinate phosphoribosyltransferase, putativ
— Both
TcYC6_0044570
hypothetical protein, conserved
— Both
TcYC6_0077340 ⚠
transcription elongation factor-like protein,
— Both
TcYC6_0108170
UBX domain-containing protein
— Both
TcYC6_0066530 ⚠
dihydroorotase, putative
— Both
TcYC6_0062220 ⚠
thioredoxin-like protein, putative
— Both
TcYC6_0063070 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— Both
TcYC6_0080210 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0074780 ⚠
isocitrate dehydrogenase, putative
— Both
TcYC6_0088930
pyroglutamyl-peptidase I, putative
— Both
TcYC6_0080140 ⚠
Elongation factor G1, mitochondrial, putative
— Both
TcYC6_0076180 ⚠
esterase, putative
— Both
TcYC6_0116190
UTP-glucose-1-phosphate uridylyltransferase 2
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.