TcYC6_0043810

metallo-peptidase, Clan MF, Family M17

Trypanosoma cruzi Y C6 OG6: OG6_142599 OG7: OG7_0003405 280 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 280 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0005350 ⚠ aminoacylase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
TcYC6_0005340 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
TcYC6_0005360 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
TcYC6_0122980 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcYC6_0044850 ⚠ exosome complex exonuclease RRP44p-like	—	OG6 LdBPK_110630.1 ↔ LdBPK_280470.1 OG6 LdBPK_110640.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 +2 more	Both
TcYC6_0017070 ⚠ putative calpain-like cysteine peptidase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcYC6_0047480 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcYC6_0084300 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG6 LdBPK_010630.1 ↔ LdBPK_110630.1 OG6 LdBPK_010630.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 +3 more	Both
TcYC6_0024850 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcYC6_0047490 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcYC6_0065870 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcYC6_0095730 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG6 LdBPK_110630.1 ↔ LdBPK_300810.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	Both
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcYC6_0026330 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcYC6_0024770 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG6 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 +1 more	Both
TcYC6_0047040 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TcYC6_0095370 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
TcYC6_0026340 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcYC6_0017040 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TcYC6_0100340 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_002376	OG7
TcYC6_0104860 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
TcYC6_0099000 ⚠ putative cyclin	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcYC6_0068840 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_352820.1	OG7
TcYC6_0122140 ⚠ flagellum transition zone component, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0122260 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0047800 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0104160 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0089210 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_250420.1 OG7 LdBPK_110640.1 ↔ LdBPK_250420.1 OG7 LdBPK_250420.1 ↔ LdBPK_332700.1	OG7
TcYC6_0113560 ⚠ macrophage infectivity potentiator, precursor	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TcYC6_0044540 ⚠ neurobeachin/beige-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_332920.1	OG7
TcYC6_0075110 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcYC6_0122250 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0113000 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TcYC6_0071260 ⚠ regulator of chromosome condensation (RCC1),	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0028290 ⚠ ubiquitin hydrolase	—	OG7 LdBPK_332700.1 ↔ LdBPK_343890.1	OG7
TcYC6_0044010 ⚠ regulator of chromatin condensation, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0127450 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0002790 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_160320.1 OG7 LdBPK_110640.1 ↔ LdBPK_160320.1 OG7 LdBPK_160320.1 ↔ LdBPK_332700.1	OG7
TcYC6_0091340 ⚠ geranylgeranyl transferase type II beta subun	—	OG7 LdBPK_110640.1 ↔ LdBPK_261450.1	OG7
TcYC6_0122330 ⚠ flagellum transition zone component, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0093940 ⚠ peptidyl-prolyl cis-trans isomerase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TcYC6_0088960 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0073500 ⚠ ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7
TcYC6_0027170 ⚠ hypothetical protein	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010621	OG7
TcYC6_0068480 ⚠ ubiquitin hydrolase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7
TcYC6_0043300 ⚠ beta-adaptin 1, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_004597	OG7

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