TcYC6_0122980

isoleucyl-tRNA synthetase, putative

Trypanosoma cruzi Y C6 OG6: OG6_100811 OG7: OG7_0003029 194 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 194 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0043810 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcYC6_0019430 ⚠ tyrosyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 Tb927.10.9190 ↔ Tb927.8.5330	Both
TcYC6_0102550 leucyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004705	Both
TcYC6_0010370 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
TcYC6_0072780 ⚠ aminopeptidase, putative,metallo-peptidase, C	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcYC6_0055270 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
TcYC6_0005350 ⚠ aminoacylase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
TcYC6_0005340 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
TcYC6_0092990 ⚠ hypothetical protein, conserved	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.4.2310 OG6 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 +1 more	Both
TcYC6_0005360 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
TcYC6_0119340 ⚠ U6 snRNA-associated Sm-like protein LSm8p	—	OG7 LdBPK_354530.1 ↔ LdBPK_365870.1 OG7 LdBPK_301270.1 ↔ LdBPK_365870.1	OG7
TcYC6_0122510 ⚠ rab-like GTPase activating protein, putative	—	OG7 TCSYLVIO_004663 ↔ TCSYLVIO_004705	OG7
TcYC6_0021560 ⚠ U6 snRNA-associated Sm-like protein LSm7p	—	OG7 LdBPK_354530.1 ↔ LdBPK_365870.1 OG7 LdBPK_301270.1 ↔ LdBPK_365870.1	OG7
TcYC6_0089210 ⚠ hypothetical protein	—	OG7 LdBPK_250420.1 ↔ LdBPK_365870.1	OG7
TcYC6_0051840 ⚠ Importin subunit beta-4, putative	—	OG7 LdBPK_070810.1 ↔ LdBPK_365870.1	OG7
TcYC6_0043870 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcYC6_0049170 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcYC6_0058570 ⚠ cytochrome b5-like Heme/Steroid binding domai	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcYC6_0109080 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcYC6_0040620 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_004705	OG7
TcYC6_0024770 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
TcYC6_0044850 ⚠ exosome complex exonuclease RRP44p-like	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
TcYC6_0075310 ⚠ hypothetical protein	—	OG6 LdBPK_250420.1 ↔ LdBPK_365870.1 OG7 LdBPK_250420.1 ↔ LdBPK_365870.1	Both
TcYC6_0095660 co-chaperone GrpE, putative	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_004705	Both
TcYC6_0125370 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004910 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004910	Both
TcYC6_0074840 protein kinase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007401	Both
TcYC6_0027170 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010621	Both
TcYC6_0120060 eukaryotic translation initiation factor 3 su	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006404	Both
TcYC6_0047190 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005125	Both
TcYC6_0068780 acyl-CoA dehydrogenase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005872 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005872	Both
TcYC6_0009840 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006877 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006877	Both
TcYC6_0005830 VHS domain containing protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008292 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008292	Both
TcYC6_0032520 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
TcYC6_0116080 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006217	OG6
TcYC6_0113630 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006012 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006012	Both
TcYC6_0127080 inositol-3-phosphate synthase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007453	Both
TcYC6_0072610 ⚠ heat shock protein 84, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005578 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005578	Both
TcYC6_0018260 ⚠ serine hydroxymethyltransferase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010621	Both
TcYC6_0107920 tryptophanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010724	OG6
TcYC6_0062970 hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010937 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010937	Both
TcYC6_0047340 ⚠ calcium/calmodulin-dependent protein kinase,	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005149 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005149	Both
TcYC6_0115250 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
TcYC6_0075560 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005414	Both
TcYC6_0047950 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_009102	Both
TcYC6_0022740 methionyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007991	Both

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