TcYC6_0044850

exosome complex exonuclease RRP44p-like

Trypanosoma cruzi Y C6 OG6: OG6_101226 OG7: OG7_0002439 241 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 241 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0027670 ⚠ tRNA synthetases class II (A)/Threonyl and Al	—	OG6 LdBPK_150720.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 LdBPK_150720.1 ↔ LdBPK_280470.1	Both
TcYC6_0074840 ⚠ protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007401 OG7 LdBPK_280470.1 ↔ LdBPK_331490.1	OG7
TcYC6_0071020 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_280470.1 ↔ LdBPK_354620.1 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005710 OG7 LdBPK_280470.1 ↔ LdBPK_354620.1	Both
TcYC6_0072780 ⚠ aminopeptidase, putative,metallo-peptidase, C	—	OG6 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
TcYC6_0005350 ⚠ aminoacylase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_280470.1 OG6 LdBPK_201740.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 +1 more	Both
TcYC6_0005340 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_280470.1 OG6 LdBPK_201740.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 +1 more	Both
TcYC6_0005360 ⚠ amidohydrolase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_280470.1 OG6 LdBPK_201740.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 +1 more	Both
TcYC6_0043810 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 LdBPK_110630.1 ↔ LdBPK_280470.1 OG6 LdBPK_110640.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 +2 more	Both
TcYC6_0127080 ⚠ inositol-3-phosphate synthase, putative	—	OG6 LdBPK_141450.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_280470.1	Both
TcYC6_0005400 ⚠ tRNA (Uracil-5-)-methyltransferase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_008409 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008409	OG7
TcYC6_0102170 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_002842	OG7
TcYC6_0058570 ⚠ cytochrome b5-like Heme/Steroid binding domai	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003124 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003124	OG7
TcYC6_0109080 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003124 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003124	OG7
TcYC6_0122510 ⚠ rab-like GTPase activating protein, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004663 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004663	OG7
TcYC6_0074690 ⚠ hypothetical protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007387	OG7
TcYC6_0120060 ⚠ eukaryotic translation initiation factor 3 su	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006404	OG7
TcYC6_0047950 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
TcYC6_0022740 ⚠ methionyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	OG7
TcYC6_0062970 ⚠ hypothetical protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010937 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010937	OG7
TcYC6_0092990 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_002526	OG7
TcYC6_0104220 ⚠ hypothetical protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010257 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010257	OG7
TcYC6_0146170 ⚠ retrotransposon hot spot (RHS) protein, putat	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010257 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010257	OG7
TcYC6_0115250 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006141	OG7
TcYC6_0002740 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006012 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006012	OG7
TcYC6_0112510 ⚠ deoxyhypusine synthase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007258	OG7
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003107	OG7
TcYC6_0047340 ⚠ calcium/calmodulin-dependent protein kinase,	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005149 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005149	OG7
TcYC6_0075560 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005414	OG7
TcYC6_0115830 ⚠ CAMK/CAMKL family protein kinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
TcYC6_0105110 ⚠ calreticulin, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_002866 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_002866	OG7
TcYC6_0116450 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004284	OG7
TcYC6_0095660 ⚠ co-chaperone GrpE, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003139	OG7
TcYC6_0126540 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004998	OG7
TcYC6_0046790 ⚠ CAMK/CAMKL family protein kinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
TcYC6_0071890 ⚠ ribosome-interacting GTPase 2, putative	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_005006	OG7
TcYC6_0100460 ⚠ CAMK/CAMKL family protein kinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
TcYC6_0098810 ⚠ DNA ligase I, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003375	OG7
TcYC6_0055270 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_002526	OG7
TcYC6_0121960 ⚠ ubiquitin-protein ligase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003155	OG7
TcYC6_0018260 ⚠ serine hydroxymethyltransferase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010621	OG7
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003107	OG7
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003107	OG7
TcYC6_0009920 ⚠ CAMK/CAMKL pseudokinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
TcYC6_0095450 ⚠ histidyl-tRNA synthetase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003126 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003126	OG7
TcYC6_0098470 ⚠ valyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003345 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003345	OG7
TcYC6_0106020 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
TcYC6_0110440 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004363 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004363	OG7
TcYC6_0049170 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003124 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003124	OG7
TcYC6_0049300 ⚠ Rab-GTPase-TBC domain containing protein, put	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_008881	OG7
TcYC6_0086020 ⚠ serine/threonine protein kinase, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005149 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005149	OG7

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