TcYC6_0121960

ubiquitin-protein ligase, putative
Trypanosoma cruzi Y C6 OG6: OG6_109174 OG7: OG7_0000785 350 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 350 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0023220 ⚠
dynein arm light chain, putative
— OG7
TcYC6_0079240 ⚠
Axonemal inner arm dynein light chain, putati
— OG7
TcYC6_0081750 ⚠
dynein light chain p28, axonemal, putative
— OG7
TcYC6_0016180 ⚠
dynein heavy chain, putative
— OG7
TcYC6_0058600 ⚠
putative dynein arm light chain
— Both
TcYC6_0043390 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0114770 ⚠
putative intraflagellar transport protein 140
— Both
TcYC6_0103040 ⚠
T-complex protein 1, zeta subunit, putative
— +4 more OG7
TcYC6_0068480 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0050640 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0043360 ⚠
PUB domain containing protein, putative
— OG7
TcYC6_0044080 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0113820 ⚠
DNA-directed RNA polymerases I and III subuni
— OG7
TcYC6_0093170 ⚠
guide RNA associated protein, GAP2, putative
— OG7
TcYC6_0108000 ⚠
DNA-directed RNA polymerase II subunit 3, put
— OG7
TcYC6_0031280 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0071370 ⚠
proteasome alpha 1 subunit, putative
— OG7
TcYC6_0117350 ⚠
proteasome alpha 7 subunit, putative
— OG7
TcYC6_0067110 ⚠
adenylate kinase, putative
— OG7
TcYC6_0019050 ⚠
proteasome alpha 3 subunit, putative
— OG7
TcYC6_0044220 ⚠
proteasome alpha 7 subunit, putative
— OG7
TcYC6_0125780 ⚠
proteasome subunit alpha type-1, putative
— OG7
TcYC6_0022090 ⚠
proteasome subunit alpha type-5, putative
— OG7
TcYC6_0023180 ⚠
proteasome alpha 2 subunit, putative
— OG7
TcYC6_0021590 ⚠
adenylate kinase, putative
— OG7
TcYC6_0125480 ⚠
adenylate kinase, putative
— OG7
TcYC6_0025330 ⚠
UMP/CMP kinase, putative
— OG7
TcYC6_0078620 ⚠
DNA polymerase delta catalytic subunit, putat
— OG7
TcYC6_0055840 ⚠
DNA polymerase I alpha catalytic subunit
— OG7
TcYC6_0052820 ⚠
RNA helicase
— OG7
TcYC6_0048640 ⚠
ATP-dependent RNA helicase, putative
— OG7
TcYC6_0101400 ⚠
ATP-dependent RNA helicase, putative
— OG7
TcYC6_0030470 ⚠
putative DNA polymerase theta (helicase domai
— OG7
TcYC6_0114220 ⚠
intraflagellar transport protein 52
— OG7
TcYC6_0004820 ⚠
histone deacetylase, putative
— OG7
TcYC6_0065500 ⚠
histone deacetylase, putative
— OG7
TcYC6_0065860 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0051300 ⚠
histone deacetylase, putative
— OG7
TcYC6_0101260 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0064120 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0023240 ⚠
Domain of unknown function (DUF4042), putativ
— OG7
TcYC6_0062910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0032500 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0119360 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0121250 ⚠
T-complex protein 1, theta subunit, putative
— +4 more OG7
TcYC6_0050130 ⚠
chaperonin alpha subunit, putative
— +4 more OG7
TcYC6_0053320 ⚠
chaperonin containing t-complex protein, puta
— +4 more OG7
TcYC6_0023210 ⚠
T-complex protein 1, delta subunit, putative
— +4 more OG7
TcYC6_0043310 ⚠
HIT zinc finger, putative
— OG7
TcYC6_0071990 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.