TcYC6_0115250

hypothetical protein, conserved

Trypanosoma cruzi Y C6 OG6: OG6_100592 OG7: OG7_0001836 137 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 137 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0086030 ⚠ serine/threonine protein kinase	—	OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006141	OG7
TcYC6_0047950 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_009102	Both
TcYC6_0120060 ⚠ eukaryotic translation initiation factor 3 su	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_006404 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_006404	Both
TcYC6_0074690 ⚠ hypothetical protein	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007387 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007387	Both
TcYC6_0027170 ⚠ hypothetical protein	—	OG6 TCSYLVIO_006141 ↔ TCSYLVIO_010621 OG6 TCSYLVIO_006140 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010621	Both
TcYC6_0074840 ⚠ protein kinase	—	OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007401 OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007401	Both
TcYC6_0075560 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006141	Both
TcYC6_0094080 ⚠ alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001889 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_006141	Both
TcYC6_0098450 ⚠ S-adenosylmethionine decarboxylase proenzyme,	—	OG6 TCSYLVIO_003342 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_003342 ↔ TCSYLVIO_006141	Both
TcYC6_0014120 ⚠ phosphonopyruvate decarboxylase, putative	—	OG6 TCSYLVIO_002596 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002596 ↔ TCSYLVIO_006141	Both
TcYC6_0110440 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG6 TCSYLVIO_004363 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004363 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_006141	Both
TcYC6_0124250 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004813 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004813 ↔ TCSYLVIO_006141	Both
TcYC6_0000250 ⚠ Gar1/Naf1 RNA binding region, putative	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_000836 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_006141	Both
TcYC6_0044260 ⚠ acidocalcisomal pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
TcYC6_0111400 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
TcYC6_0042390 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001973 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_006141	Both
TcYC6_0122980 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
TcYC6_0030310 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_000215 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_000215 ↔ TCSYLVIO_006141	Both
TcYC6_0113630 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_006012 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	Both
TcYC6_0044850 ⚠ exosome complex exonuclease RRP44p-like	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006141	OG7
TcYC6_0024770 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006141	OG7
TcYC6_0090570 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006141	OG7
TcYC6_0040620 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006141	OG7
TcYC6_0109080 ⚠ cytochrome b5, putative	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006141	OG7
TcYC6_0058570 ⚠ cytochrome b5-like Heme/Steroid binding domai	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006141	OG7
TcYC6_0049170 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006141	OG7
TcYC6_0043870 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003124 ↔ TCSYLVIO_006141	OG7
TcYC6_0124530 ⚠ ATP-binding cassette sub-family F member 1, p	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
TcYC6_0004090 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
TcYC6_0002740 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
TcYC6_0024170 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
TcYC6_0029650 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
TcYC6_0075720 ⚠ calcium/calmodulin-dependent protein kinase,	—	OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006141	OG7
TcYC6_0086070 ⚠ serine/threonine protein kinase	—	OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006141	OG7
TcYC6_0113920 ⚠ protein kinase	—	OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005149 ↔ TCSYLVIO_006141	OG7
TcYC6_0104220 ⚠ hypothetical protein	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010257 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010257	OG7
TcYC6_0119750 ⚠ mitochondrial import inner membrane transloca	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
TcYC6_0106020 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_009102	OG7
TcYC6_0055270 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010624	OG7
TcYC6_0110800 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
TcYC6_0080270 ⚠ dihydrouridine synthase, putative	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_009102	OG7
TcYC6_0068670 ⚠ TFIIF-stimulated CTD phosphatase, putative	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
TcYC6_0125080 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
TcYC6_0146170 ⚠ retrotransposon hot spot (RHS) protein, putat	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010257 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010257	OG7
TcYC6_0069010 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000834 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_006141	OG7
TcYC6_0082630 ⚠ translation initiation factor IF-2, putative	—	OG7 TCSYLVIO_001768 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_006141	OG7
TcYC6_0048880 ⚠ NOL1/NOP2/sun family, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006141	OG7
TcYC6_0116460 ⚠ Multisite-specific tRNA:(cytosine-C(5))-methy	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006141	OG7
TcYC6_0121410 ⚠ nuclear lim interactor-interacting factor, pu	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
TcYC6_0092990 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010624	OG7

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