TcYC6_0072780

aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17, putative

Trypanosoma cruzi Y C6 OG6: OG6_105603 OG7: OG7_0003405 267 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 267 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0005350 ⚠ aminoacylase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
TcYC6_0005340 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
TcYC6_0005360 ⚠ amidohydrolase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
TcYC6_0095730 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	OG7
TcYC6_0044850 ⚠ exosome complex exonuclease RRP44p-like	—	OG6 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
TcYC6_0122980 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TcYC6_0095370 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	OG7
TcYC6_0065870 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	OG7
TcYC6_0047040 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcYC6_0047490 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
TcYC6_0024770 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
TcYC6_0047480 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
TcYC6_0084300 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 LdBPK_010630.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG7 LdBPK_010630.1 ↔ LdBPK_110630.1 OG7 LdBPK_010630.1 ↔ LdBPK_332700.1 +1 more	Both
TcYC6_0127450 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0042250 ⚠ CYC2-like cyclin 4, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcYC6_0107490 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
TcYC6_0012520 ⚠ p21-C-terminal region-binding protein, putati	—	OG7 LdBPK_110640.1 ↔ LdBPK_282030.1	OG7
TcYC6_0088160 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_341230.1 OG7 LdBPK_110640.1 ↔ LdBPK_341230.1 OG7 LdBPK_332700.1 ↔ LdBPK_341230.1	OG7
TcYC6_0056280 ⚠ putative regulator of chromosome condensation	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0104860 ⚠ CRAL/TRIO domain containing protein, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
TcYC6_0099000 ⚠ putative cyclin	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcYC6_0068840 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_352820.1	OG7
TcYC6_0122140 ⚠ flagellum transition zone component, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0122260 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0047800 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0104160 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0056290 ⚠ protein farnesyltransferase, putative	—	OG7 LdBPK_110640.1 ↔ LdBPK_261450.1	OG7
TcYC6_0089210 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_250420.1 OG7 LdBPK_110640.1 ↔ LdBPK_250420.1 OG7 LdBPK_250420.1 ↔ LdBPK_332700.1	OG7
TcYC6_0113560 ⚠ macrophage infectivity potentiator, precursor	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TcYC6_0044540 ⚠ neurobeachin/beige-like protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_332920.1	OG7
TcYC6_0025640 ⚠ inosine-5'-monophosphate dehydrogenase, putat	—	OG7 LdBPK_110640.1 ↔ LdBPK_191590.1	OG7
TcYC6_0023240 ⚠ Domain of unknown function (DUF4042), putativ	—	OG7 LdBPK_110640.1 ↔ LdBPK_211060.1	OG7
TcYC6_0075110 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
TcYC6_0122250 ⚠ hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_366480.1 OG7 LdBPK_110640.1 ↔ LdBPK_366480.1 OG7 LdBPK_332700.1 ↔ LdBPK_366480.1	OG7
TcYC6_0113000 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TcYC6_0071260 ⚠ regulator of chromosome condensation (RCC1),	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TcYC6_0072130 ⚠ hypothetical protein	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005619	OG7
TcYC6_0084200 ⚠ ubiquitin activating enzyme, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010542	OG7
TcYC6_0104220 ⚠ hypothetical protein	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_001670	OG7
TcYC6_0146170 ⚠ retrotransposon hot spot (RHS) protein, putat	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_001670	OG7
TcYC6_0111400 ⚠ inorganic pyrophosphatase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_001709	OG7
TcYC6_0100340 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_002376	OG7
TcYC6_0064660 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003586	OG7
TcYC6_0085910 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003586	OG7
TcYC6_0046920 ⚠ vacuolar ATP synthase subunit d	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005104	OG7

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