TcYC6_0065870

hypothetical protein, conserved

Trypanosoma cruzi Y C6 OG6: OG6_107301 OG7: OG7_0010331 192 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 192 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0066100 ⚠ ubiquitin-activating enzyme	—	OG6 LdBPK_080230.1 ↔ LdBPK_080420.1 OG6 TCSYLVIO_010542 ↔ TCSYLVIO_010560 OG7 LdBPK_080230.1 ↔ LdBPK_080420.1 OG7 TCSYLVIO_010542 ↔ TCSYLVIO_010560	Both
TcYC6_0124540 ⚠ heat shock protein 85, putative	—	OG6 TCSYLVIO_009151 ↔ TCSYLVIO_010560 OG6 TCSYLVIO_009400 ↔ TCSYLVIO_010560 OG6 TCSYLVIO_008621 ↔ TCSYLVIO_010560 OG7 Tb927.3.3580 ↔ Tb927.5.3260 +3 more	Both
TcYC6_0124550 ⚠ putative heat shock protein 85	—	OG6 TCSYLVIO_009151 ↔ TCSYLVIO_010560 OG6 TCSYLVIO_009400 ↔ TCSYLVIO_010560 OG6 TCSYLVIO_008621 ↔ TCSYLVIO_010560 OG7 Tb927.3.3580 ↔ Tb927.5.3260 +3 more	Both
TcYC6_0095370 hypothetical protein, conserved	—	OG6 LdBPK_080420.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_300580.1	Both
TcYC6_0108590 ⚠ heat shock protein 90, putative	—	OG6 Tb927.3.3580 ↔ Tb927.5.3260 OG7 Tb927.3.3580 ↔ Tb927.5.3260 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010560 +1 more	Both
TcYC6_0083670 tubulin folding cofactor D, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_010560	Both
TcYC6_0072780 ⚠ aminopeptidase, putative,metallo-peptidase, C	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	OG7
TcYC6_0084200 ⚠ ubiquitin activating enzyme, putative	—	OG7 LdBPK_080230.1 ↔ LdBPK_080420.1 OG7 TCSYLVIO_010542 ↔ TCSYLVIO_010560	OG7
TcYC6_0021550 ⚠ hypothetical protein	—	OG7 TCSYLVIO_005619 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_332020.1	OG7
TcYC6_0072610 ⚠ heat shock protein 84, putative	—	OG7 Tb927.3.3580 ↔ Tb927.5.3260 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_010560	OG7
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_342110.1	OG7
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_342110.1	OG7
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_342110.1	OG7
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_342110.1	OG7
TcYC6_0115710 hypothetical protein, conserved	—	OG6 Tb927.10.14030 ↔ Tb927.5.3260 OG6 LdBPK_080420.1 ↔ LdBPK_180550.1 OG7 Tb927.10.14030 ↔ Tb927.5.3260 OG7 LdBPK_080420.1 ↔ LdBPK_180550.1	Both
TcYC6_0072130 ⚠ hypothetical protein	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_332020.1	Both
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_342110.1	Both
TcYC6_0072920 phenylalanyl-tRNA synthetase (beta subunit),	—	OG6 TCSYLVIO_005548 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_191010.1 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_191010.1	Both
TcYC6_0061260 ⚠ helicase, putative	—	OG6 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_120255.1 OG7 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_120255.1	Both
TcYC6_0043810 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
TcYC6_0061240 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_120255.1 OG7 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_120255.1	Both
TcYC6_0061280 ⚠ helicase, putative	—	OG6 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_120255.1 OG7 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_120255.1	Both
TcYC6_0061220 ⚠ helicase, putative	—	OG6 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_120255.1 OG7 TCSYLVIO_006977 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_120255.1	Both
TcYC6_0032520 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010560	Both
TcYC6_0107860 ⚠ nuclear transcription factor, putative	—	OG7 LdBPK_080420.1 ↔ LdBPK_220007.1	OG7
TcYC6_0073500 ⚠ ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_010560	OG7
TcYC6_0068480 ⚠ ubiquitin hydrolase, putative	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_010560	OG7
TcYC6_0092100 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_080420.1 ↔ LdBPK_161180.1 OG7 LdBPK_080420.1 ↔ LdBPK_300970.1	OG7
TcYC6_0053250 ⚠ small nuclear ribonucleoprotein Sm-G, putativ	—	OG7 LdBPK_080420.1 ↔ LdBPK_260010.1	OG7
TcYC6_0028200 ⚠ putative inositol/phosphatidylinositol phosph	—	OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010560	OG7
TcYC6_0081730 ⚠ putative synaptojanin	—	OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010560	OG7
TcYC6_0079620 ⚠ endonuclease/exonuclease/phosphatase, putativ	—	OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010560	OG7
TcYC6_0070640 ⚠ synaptojanin (N-terminal domain), putative	—	OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010560	OG7
TcYC6_0088260 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010560	OG7
TcYC6_0126250 ⚠ PIF1 helicase-like protein	—	OG7 LdBPK_030430.1 ↔ LdBPK_080420.1	OG7
TcYC6_0045680 ⚠ TLD, putative	—	OG7 LdBPK_030430.1 ↔ LdBPK_080420.1	OG7
TcYC6_0068420 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_010560	OG7
TcYC6_0100340 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_010560	OG7
TcYC6_0111530 ⚠ 6-phosphofructo-2-kinase 1	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_010560	OG7
TcYC6_0080710 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_010560	OG7
TcYC6_0045770 ⚠ hypothetical protein	—	OG7 LdBPK_030430.1 ↔ LdBPK_080420.1	OG7
TcYC6_0121920 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_010560	Both
TcYC6_0120270 ⚠ putative Leucine rich repeat	—	OG6 TCSYLVIO_006421 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_006421 ↔ TCSYLVIO_010560	Both
TcYC6_0120590 ⚠ putative Leucine rich repeat	—	OG6 TCSYLVIO_006421 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_006421 ↔ TCSYLVIO_010560	Both
TcYC6_0064660 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_010560	Both
TcYC6_0085910 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_010560	Both
TcYC6_0114860 Histone chaperone Rttp106-like, putative	—	OG6 TCSYLVIO_006113 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_006113 ↔ TCSYLVIO_010560	Both
TcYC6_0083540 WD domain, G-beta repeat/PFU (PLAA family ubi	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_010560	Both
TcYC6_0005960 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_010560	OG7
TcYC6_0084300 DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_003428 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_010560	Both

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