TcYC6_0108590

heat shock protein 90, putative

Trypanosoma cruzi Y C6 OG6: OG6_143062 OG7: OG7_0001978 163 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 163 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0115710 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_006181 ↔ TCSYLVIO_010666 OG6 Tb927.10.14030 ↔ Tb927.3.3580 OG7 TCSYLVIO_006181 ↔ TCSYLVIO_010666 OG7 Tb927.10.14030 ↔ Tb927.3.3580	Both
TcYC6_0028640 ⚠ putative glutamate dehydrogenase	—	OG7 LdBPK_151070.1 ↔ LdBPK_330360.1 OG7 TCSYLVIO_007064 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007064 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007064 ↔ TCSYLVIO_009151 +1 more	OG7
TcYC6_0055270 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	OG7
TcYC6_0092990 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	OG7
TcYC6_0010370 ⚠ tyrosyl or methionyl-tRNA synthetase, putativ	—	OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	OG7
TcYC6_0019430 ⚠ tyrosyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	OG7
TcYC6_0124550 ⚠ putative heat shock protein 85	—	OG7 LdBPK_290790.1 ↔ LdBPK_330360.1 OG7 TCSYLVIO_002205 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008593 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009400 +4 more	OG7
TcYC6_0072610 ⚠ heat shock protein 84, putative	—	OG7 LdBPK_290790.1 ↔ LdBPK_330360.1 OG7 TCSYLVIO_002205 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008593 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009400 +4 more	OG7
TcYC6_0065870 ⚠ hypothetical protein, conserved	—	OG6 Tb927.3.3580 ↔ Tb927.5.3260 OG7 Tb927.3.3580 ↔ Tb927.5.3260 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010560 +1 more	Both
TcYC6_0124540 ⚠ heat shock protein 85, putative	—	OG7 LdBPK_290790.1 ↔ LdBPK_330360.1 OG7 TCSYLVIO_002205 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008593 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009400 +4 more	OG7
TcYC6_0030660 ⚠ coronin, putative	—	OG7 Tb927.10.10960 ↔ Tb927.8.3100 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_009151	OG7
TcYC6_0072920 ⚠ phenylalanyl-tRNA synthetase (beta subunit),	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_009151	OG7
TcYC6_0005960 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_009151	OG7
TcYC6_0052180 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004111 ↔ TCSYLVIO_011092	OG7
TcYC6_0053470 ⚠ phenylalanyl-tRNA synthetase alpha chain, put	—	OG7 TCSYLVIO_004213 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_009151	OG7
TcYC6_0062940 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_008446 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008446 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_008446 ↔ TCSYLVIO_009151	OG7
TcYC6_0114860 ⚠ Histone chaperone Rttp106-like, putative	—	OG7 TCSYLVIO_006113 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_006113 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_006113 ↔ TCSYLVIO_009151	OG7
TcYC6_0114060 ⚠ nucleosome assembly protein, putative	—	OG7 TCSYLVIO_007060 ↔ TCSYLVIO_008593 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_009151 +1 more	OG7
TcYC6_0028140 ⚠ nucleosome assembly protein-like protein, put	—	OG7 TCSYLVIO_007060 ↔ TCSYLVIO_008593 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_009151 +1 more	OG7
TcYC6_0084300 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG7 TCSYLVIO_003428 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_009151	OG7
TcYC6_0028450 ⚠ glutaminyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003355 ↔ TCSYLVIO_005578	OG7
TcYC6_0098600 ⚠ glutamyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003355 ↔ TCSYLVIO_005578	OG7
TcYC6_0047480 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0047490 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0047040 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0126920 ⚠ serine peptidase, Clan SC, Family S9B	—	OG7 TCSYLVIO_007536 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007536 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007536 ↔ TCSYLVIO_009151	OG7
TcYC6_0042030 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0042040 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0041990 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0041970 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0042020 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0042010 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0042000 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0041980 ⚠ ATP synthase F1, alpha subunit	—	OG7 TCSYLVIO_001942 ↔ TCSYLVIO_002205	OG7
TcYC6_0017360 ⚠ putative developmentally regulated phosphopro	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0080930 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0091190 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0043840 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001673 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001673 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001673 ↔ TCSYLVIO_009151	OG7
TcYC6_0123050 ⚠ adenylyl cyclase-associated protein, putative	—	OG7 TCSYLVIO_004711 ↔ TCSYLVIO_005578	OG7
TcYC6_0009900 ⚠ vacuolar protein sorting-associated protein 3	—	OG7 LdBPK_210530.1 ↔ LdBPK_332520.1	OG7
TcYC6_0092290 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001150 ↔ TCSYLVIO_005578	OG7
TcYC6_0062380 ⚠ threonyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007511 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007511 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007511 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_002205 ↔ TCSYLVIO_007511	OG7
TcYC6_0091400 ⚠ GRIP domain containing protein, putative	—	OG7 TCSYLVIO_003707 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_003707 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_003707 ↔ TCSYLVIO_009151	OG7
TcYC6_0142810 ⚠ retrotransposon hot spot (RHS) protein, putat	—	OG7 TCSYLVIO_005578 ↔ TCSYLVIO_010309 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_006596 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_009400 +3 more	OG7
TcYC6_0005360 ⚠ amidohydrolase, putative	—	OG7 TCSYLVIO_005578 ↔ TCSYLVIO_008414	OG7
TcYC6_0126540 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_005578	OG7
TcYC6_0110960 ⚠ NOL1/NOP2/sun family, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_005578	OG7
TcYC6_0048880 ⚠ NOL1/NOP2/sun family, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_005578	OG7
TcYC6_0116460 ⚠ Multisite-specific tRNA:(cytosine-C(5))-methy	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_005578	OG7
TcYC6_0073450 ⚠ arginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_005509 ↔ TCSYLVIO_005578	OG7

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