TcYC6_0091400

GRIP domain containing protein, putative
Trypanosoma cruzi Y C6 OG6: OG6_147115 OG7: OG7_0043222 252 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 252 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0121420 ⚠
beta adaptin, putative
— Both
TcYC6_0005960 ⚠
Adaptor protein complex AP-3 subunit beta-3
— Both
TcYC6_0050640 ⚠
ubiquitin hydrolase, putative
— Both
TcYC6_0123030 ⚠
beta adaptin, putative
— OG7
TcYC6_0043300 ⚠
beta-adaptin 1, putative
— OG7
TcYC6_0068480 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0073500 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
TcYC6_0048650 ⚠
formin, putative
— OG7
TcYC6_0075700 ⚠
tubulin-tyrosine ligase, putative
— OG7
TcYC6_0115520 ⚠
tubulin tyrosine ligase protein, putative
— OG7
TcYC6_0097300 ⚠
tubulin-tyrosine ligase-like protein, putativ
— OG7
TcYC6_0005550 ⚠
Myotubularin-related protein, putative
— OG7
TcYC6_0061110 ⚠
Myotubularin-related protein, putative
— OG7
TcYC6_0068420 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0077210 ⚠
DNA replication licensing factor MCM3, putati
— OG7
TcYC6_0036090 ⚠
DNA replication licensing factor MCM4, putati
— OG7
TcYC6_0175620 ⚠
DNA replication licensing factor MCM8, putati
— OG7
TcYC6_0050600 ⚠
DNA replication licensing factor MCM7, putati
— OG7
TcYC6_0012040 ⚠
DNA replication licensing factor MCM6
— OG7
TcYC6_0003610 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcYC6_0072160 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcYC6_0081820 ⚠
DNA replication licensing factor MCM5
— OG7
TcYC6_0071440 ⚠
DNA replication licensing factor MCM9, putati
— OG7
TcYC6_0123300 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcYC6_0006510 ⚠
ubiquitin-domain-containing protein (fragment
— OG7
TcYC6_0037180 ⚠
ubiquitin-60S ribosomal protein L40
— OG7
TcYC6_0065270 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
TcYC6_0037170 ⚠
polyubiquitin
— OG7
TcYC6_0037160 ⚠
polyubiquitin
— OG7
TcYC6_0018310 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
TcYC6_0080110 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
TcYC6_0100340 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
TcYC6_0111530 ⚠
6-phosphofructo-2-kinase 1
— OG7
TcYC6_0080710 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
TcYC6_0121960 ⚠
ubiquitin-protein ligase, putative
— OG7
TcYC6_0092100 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0064660 ⚠
hypothetical protein, conserved
— Both
TcYC6_0005640
hypothetical protein, conserved
— Both
TcYC6_0127790
hypothetical protein
— Both
TcYC6_0126320
hypothetical protein, conserved
— Both
TcYC6_0122890
hypothetical protein, conserved
— Both
TcYC6_0065750 ⚠
ribose-phosphate pyrophosphokinase, putative
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0044260 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcYC6_0083740
hypothetical protein, conserved
— Both
TcYC6_0121920 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcYC6_0063680
AKAP7 2'5' RNA ligase-like domain containing
— Both
TcYC6_0018790
WD domain, G-beta repeat/Dip2/Utp12 Family, p
— Both
TcYC6_0096290
hypothetical protein, conserved
— Both
TcYC6_0085910 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.