TcYC6_0100340

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative
Trypanosoma cruzi Y C6 OG6: OG6_100250 OG7: OG7_0002306 165 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 165 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0124680 ⚠
hypothetical protein, conserved
— Both
TcYC6_0069000 ⚠
Leucine carboxyl methyltransferase/Cupin-like
— Both
TcYC6_0123380 ⚠
hypothetical protein, conserved
— Both
TcYC6_0080770 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcYC6_0113040 ⚠
eukaryotic translation initiation factor 4E (
— OG7
TcYC6_0021550 ⚠
hypothetical protein
— OG7
TcYC6_0050640 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0043300 ⚠
beta-adaptin 1, putative
— OG7
TcYC6_0018650 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0007460 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0070640 ⚠
synaptojanin (N-terminal domain), putative
— OG7
TcYC6_0024530 ⚠
inositol 5-phosphatase 1
— OG7
TcYC6_0042410 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcYC6_0142880 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0061240 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0066100 ⚠
ubiquitin-activating enzyme
— OG7
TcYC6_0069500 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0073420 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0123030 ⚠
beta adaptin, putative
— OG7
TcYC6_0089450 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0072050 ⚠
Tcc1i14-2.10
— OG7
TcYC6_0005960 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcYC6_0074310 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcYC6_0079620 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
TcYC6_0062380 ⚠
threonyl-tRNA synthetase, putative
— OG7
TcYC6_0124540 ⚠
heat shock protein 85, putative
— OG7
TcYC6_0065870 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0088920 ⚠
Zeta toxin, putative
— OG7
TcYC6_0108590 ⚠
heat shock protein 90, putative
— OG7
TcYC6_0032520 ⚠
GDP-mannose pyrophosphorylase
— OG7
TcYC6_0073050 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
TcYC6_0018460 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0095240 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcYC6_0011810 ⚠
Eukaryotic translation initiation factor 4E-3
— OG7
TcYC6_0061260 ⚠
helicase, putative
— OG7
TcYC6_0015540 ⚠
dihydrolipoamide branched chain transacylase,
— OG7
TcYC6_0095730 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080250 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcYC6_0072610 ⚠
heat shock protein 84, putative
— OG7
TcYC6_0061280 ⚠
helicase, putative
— OG7
TcYC6_0081730 ⚠
putative synaptojanin
— OG7
TcYC6_0124550 ⚠
putative heat shock protein 85
— OG7
TcYC6_0080930 ⚠
pyruvate dehydrogenase (lipoamide) kinase, pu
— OG7
TcYC6_0034770 ⚠
ribonucleoprotein p18, mitochondrial precurso
— OG7
TcYC6_0068420 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0059460 ⚠
pseudouridylate synthase I, putative
— OG7
TcYC6_0083540 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— OG7
TcYC6_0121920 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0031230 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0073500 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.